Evidence map›Paper›PMID 31221776›Full record

ArticleHaematologica2020

Rac1/2 activation promotes FGFR1 driven leukemogenesis in stem cell leukemia/lymphoma syndrome.

Tianxiang Hu, Yating Chong, Sumin Lu, Meaghan McGuinness, David A Williams, John K Cowell

Open access · goldAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Haematologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Tianxiang HuGeorgia Cancer Center, 1410 Laney Walker Blvd., Augusta GA tihu@augusta.edu.
Yating ChongGeorgia Cancer Center, 1410 Laney Walker Blvd., Augusta GA.
Sumin LuGeorgia Cancer Center, 1410 Laney Walker Blvd., Augusta GA.
Meaghan McGuinnessDivision of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
David A WilliamsDivision of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
John K CowellGeorgia Cancer Center, 1410 Laney Walker Blvd., Augusta GA.
National Cancer Center of Georgia · GEBoston Children's Hospital · USHarvard University · USWalker (United States) · US

Funding

GENETIC ANALYSIS OF MYELOPROLIFERATIVE DISEASER01CA076167 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI COWELL, JOHN K · 1999 to 2024
$6.2M
Development of novel selective Rac inhibitors for refractory leukemiasR01CA202756 · NCI · BOSTON CHILDREN'S HOSPITAL · PI WILLIAMS, DAVID A · 2016 to 2020
$3.0M
NCI NIH HHS R01 CA076167NCI NIH HHS R01 CA202756
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

LeukemiaLymphomaAnimalsCarcinogenesisMiceNeuropeptidesrac1 GTP-Binding ProteinRAC2 GTP-Binding Proteinrac GTP-Binding ProteinsReceptor, Fibroblast Growth Factor, Type 1Stem CellsFgfr1 protein, mouseNeuropeptidesrac1 GTP-Binding ProteinRac1 protein, mouseRAC2 GTP-Binding Proteinrac GTP-Binding ProteinsReceptor, Fibroblast Growth Factor, Type 1

Identifiers

PMID31221776
PMCPMC7012474
OpenAlexW2952680059

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.