Evidence map›Paper›PMID 31221742›Full record

ArticleThe Journal of experimental medicine2019

Widespread B cell perturbations in HIV-1 infection afflict naive and marginal zone B cells.

Thomas Liechti, Claus Kadelka, Dominique L Braun, Herbert Kuster, Jürg Böni, Melissa Robbiani, Huldrych F Günthard, Alexandra Trkola

Abstract read
In one paragraph

Article in The Journal of experimental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. High Frequency of Circulating IL-4RJournal of clinical and translational hepatology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Thomas LiechtiInstitute of Medical Virology, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-8738-6679
Claus KadelkaInstitute of Medical Virology, University of Zurich, Zurich, Switzerland.
Dominique L BraunInstitute of Medical Virology, University of Zurich, Zurich, Switzerland.ORCID 0000-0003-4036-1030
Herbert KusterInstitute of Medical Virology, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-6873-0091
Jürg BöniInstitute of Medical Virology, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-7925-4852
Melissa RobbianiCenter for Biomedical Research, Population Council, New York, NY.ORCID 0000-0003-3570-8255
Huldrych F GünthardInstitute of Medical Virology, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-1142-6723
Alexandra TrkolaInstitute of Medical Virology, University of Zurich, Zurich, Switzerland trkola.alexandra@virology.uzh.ch.ORCID 0000-0003-1013-876X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Perturbations in B cells are a hallmark of HIV-1 infection. This is signified by increased numbers of exhausted CD21

Indexed as

AlgorithmsAntiretroviral Therapy, Highly ActiveApoptosisBiomarkersB-LymphocytesB-Lymphocyte SubsetsCell ProliferationClonal AnergyHIV-1HIV InfectionsHumansLymphocyte ActivationPhenotypeReceptors, ChemokineReceptors, Complement 3dReceptors, Interleukin-21BiomarkersReceptors, ChemokineReceptors, Complement 3dReceptors, Interleukin-21

Identifiers

PMID31221742
PMCPMC6719425

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.