Evidence map›Paper›PMID 31221718›Full record

ArticleThe Journal of biological chemistry2019

Discovery of an intrasubunit nicotinic acetylcholine receptor-binding site for the positive allosteric modulator Br-PBTC.

Jack Norleans, Jingyi Wang, Alexander Kuryatov, Abba Leffler, Christelle Doebelin, Theodore M Kamenecka, Jon Lindstrom

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jack NorleansDepartment of Neuroscience, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Jingyi WangDepartment of Neuroscience, University of Texas at Austin, Austin, Texas 78712.
Alexander KuryatovDepartment of Neuroscience, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Abba LefflerNeuroscience Graduate Program, Sackler Institute of Graduate Biomedical Sciences, New York University School of Medicine, New York, New York 10010.
Christelle DoebelinDepartment of Molecular Medicine, The Scripps Research Institute, Scripps, Florida, Jupiter, Florida 33458.
Theodore M KameneckaDepartment of Molecular Medicine, The Scripps Research Institute, Scripps, Florida, Jupiter, Florida 33458.
Jon LindstromDepartment of Neuroscience, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104. Electronic address: jslkk@pennmedicine.upenn.edu.

Funding

Development of a5* nAChR positive allosteric modulators for tobacco dependenceR01DA030929 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI KENNY, PAUL J., LINDSTROM, JON MARTIN · 2011 to 2015
$7.1M
NIDA NIH HHS R01 DA030929
6 · The paper itself

Abstract

Nicotinic acetylcholine receptor (nAChR) ligands that lack agonist activity but enhance activation in the presence of an agonist are called positive allosteric modulators (PAMs). nAChR PAMs have therapeutic potential for the treatment of nicotine addiction and several neuropsychiatric disorders. PAMs need to be selectively targeted toward certain nAChR subtypes to tap this potential. We previously discovered a novel PAM, (

Indexed as

Allosteric RegulationAmino Acid SequenceAnimalsBinding SitesHumansKineticsMolecular Docking SimulationMutagenesis, Site-DirectedNicotinic AgonistsOocytesPatch-Clamp TechniquesPiperidinesProtein Structure, TertiaryProtein SubunitsReceptors, NicotinicRecombinant ProteinsbenzothiopheneNicotinic AgonistsPiperidinesProtein Subunits(R)-7-bromo-N-(piperidin-3-yl)benzo(b)thiophene-2-carboxamideReceptors, NicotinicRecombinant ProteinsThiophenesallosteric regulationdrug designmolecular dockingnicotinic acetylcholine receptors (nAChR)positive allosteric modulatorreceptor desensitization

Identifiers

PMID31221718
PMCPMC6690704

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.