Evidence map›Paper›PMID 31221693›Full record

Trial reportDiabetes care2019

Program ACTIVE II: Outcomes From a Randomized, Multistate Community-Based Depression Treatment for Rural and Urban Adults With Type 2 Diabetes.

Mary de Groot, Jay H Shubrook, W Guyton Hornsby, Yegan Pillay, Kieren J Mather, Karen Fitzpatrick, Ziyi Yang, Chandan Saha

Registry-linked trialOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03371940 (Program ACTIVE II), which is not on this map. Cited by 28 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 8 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03371940 nacompletednot on this map

Program ACTIVE II: Behavioral Depression Treatment for Type 2 Diabetes

TypeinterventionalSponsorIndiana UniversityRan2012 to 2017Enrolled140ConditionsType2 Diabetes, DepressionArmsProgram ACTIVE Exercise, Program ACTIVE CBT, Program ACTIVE, Usual Care - No intervention
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 8 syntheses or guidelines pooled it, 55 citations in OpenAlex.

  1. How effective are CBT and CBT-based interventions in Type 1 and Type 2 diabetes? An umbrella review.Diabetic medicine : a journal of the British Diabetic Association · 2026
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  5. American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2022
    Guideline
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Mary de GrootIndiana University School of Medicine, Indianapolis, IN mdegroot@iu.edu.ORCID 0000-0003-4021-8824
Jay H ShubrookTouro University California College of Osteopathic Medicine, Vallejo, CA.
W Guyton HornsbyWest Virginia University School of Medicine, Morgantown, WV.
Yegan PillayOhio University, Athens, OH.
Kieren J MatherIndiana University School of Medicine, Indianapolis, IN.ORCID 0000-0001-8696-7500
Karen FitzpatrickWest Virginia University School of Medicine, Morgantown, WV.
Ziyi YangIndiana University School of Medicine, Indianapolis, IN.
Chandan SahaIndiana University School of Medicine, Indianapolis, IN.
Indiana University School of MedicineWest Virginia University · USOhio University · USTouro University California · US

Funding

Program ACTIVE II: Behavioral Depression Treatment for Type 2 DiabetesR18DK092765 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI DE GROOT, MARY K. · 2011 to 2015
$3.2M
Depression Treatment for Type 2 Diabetes AppalachiansR34DK071545 · NIDDK · OHIO UNIVERSITY ATHENS · PI DE GROOT, MARY K. · 2006 to 2007
$432k
NIDDK NIH HHS R18 DK092765NIDDK NIH HHS R34 DK071545
6 · The paper itself

Abstract

objectiveDepression (major depressive disorder [MDD]) in adults with type 2 diabetes mellitus (T2DM) is associated with worsened diabetes complications, increased health care costs, and early mortality. Program ACTIVE II was a randomized, controlled, multicenter treatment trial designed to test the comparative effectiveness of cognitive behavioral therapy (CBT) and/or community-based exercise (EXER) on diabetes and depression outcomes compared with usual care (UC). RESEARCH DESIGN AND

methodsUsing a 2 × 2 factorial randomized controlled trial design, adults with T2DM for ≥1 year who met DSM-IV-TR criteria for MDD were randomized to CBT (10 sessions occurring over 12 weeks;

resultsThe mean age was 56.0 years (SD 10.7). Participants were female (77%), white (71%), and married (52%). After controlling for education and antidepressant use, odds of achieving full MDD remission in the intervention groups were 5.0-6.8 times greater than UC (

conclusionsThe Program ACTIVE behavioral treatment interventions demonstrated clinically meaningful improvements in depression outcomes in adults with T2DM and MDD. These community-based interventions are complementary to medical care and extend access to those in rural and urban areas.

Indexed as

AdultAgedAntidepressive AgentsBlood GlucoseCognitive Behavioral TherapyCombined Modality TherapyCommunity Health ServicesDepressionDiabetes Mellitus, Type 2Exercise TherapyFemaleHumansMajor Depressive DisorderMaleMiddle AgedRural PopulationAntidepressive AgentsBlood Glucose

Identifiers

PMID31221693
PMCPMC6609961
OpenAlexW2945646820

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.