Evidence map›Paper›PMID 31221666›Full record

ArticleGenetics2019

Chromatin Modifiers Alter Recombination Between Divergent DNA Sequences.

Ujani Chakraborty, Beata Mackenroth, David Shalloway, Eric Alani

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ujani ChakrabortyDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853-2703.
Beata MackenrothDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853-2703.
David ShallowayDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853-2703.
Eric AlaniDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853-2703 eea3@cornell.edu.ORCID 0000-0002-5011-9339
Cornell University · US

Funding

Roles for Mismatch Repair Proteins in Maintaining Genome StabilityR01GM053085 · NIGMS · CORNELL UNIVERSITY ITHACA · PI ALANI, ERIC E. · 1995 to 2019
$7.3M
Roles for Mismatch Repair Proteins in Maintaining Genome StabilityR35GM134872 · NIGMS · CORNELL UNIVERSITY · PI Eric E. Alani · 2020 to 2026
$2.8M
NIGMS NIH HHS R01 GM053085NIGMS NIH HHS R35 GM134872
6 · The paper itself

Abstract

Recombination between divergent DNA sequences is actively prevented by heteroduplex rejection mechanisms. In baker's yeast, such antirecombination mechanisms can be initiated by the recognition of DNA mismatches in heteroduplex DNA by MSH proteins, followed by recruitment of the Sgs1-Top3-Rmi1 helicase-topoisomerase complex to unwind the recombination intermediate. We previously showed that the repair/rejection decision during single-strand annealing recombination is temporally regulated by MSH (

Indexed as

Histone CodeHomologous RecombinationHistone ChaperonesHistone DeacetylasesMolecular ChaperonesNucleosomesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSilent Information Regulator Proteins, Saccharomyces cerevisiaeSirtuin 2Histone ChaperonesHistone DeacetylasesHst3 protein, S cerevisiaeHst4 protein, S cerevisiaeMolecular ChaperonesNucleosomesRPD3 protein, S cerevisiaeRtt106 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsSilent Information Regulator Proteins, Saccharomyces cerevisiaeSIR2 protein, S cerevisiaeSirtuin 2chromatin modifiersheteroduplex rejectionhistone chaperoneshomologous recombinationmismatch repair

Identifiers

PMID31221666
PMCPMC6707472
OpenAlexW2950717858

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.