Evidence map›Paper›PMID 31221640›Full record

ArticleDevelopment (Cambridge, England)2019

Bone morphology is regulated modularly by global and regional genetic programs.

Shai Eyal, Shiri Kult, Sarah Rubin, Sharon Krief, Neta Felsenthal, Kyriel M Pineault, Dena Leshkowitz, Tomer-Meir Salame, Yoseph Addadi, Deneen M Wellik and 1 more

Abstract read
In one paragraph

Article in Development (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Review
  3. Interfacial Tissue Regeneration with Bone.Current osteoporosis reports · 2024
    Review
  4. Comprehensive summary: the role of PBX1 in development and cancers.Frontiers in cell and developmental biology · 2024
    Review
  5. Loss of Fgfr1 and Fgfr2 in Scleraxis-lineage cells leads to enlarged bone eminences and attachment cell death.Developmental dynamics : an official publication of the American Association of Anatomists · 2023
    Article
  6. Article
  7. Article
  8. Growth and mechanobiology of the tendon-bone enthesis.Seminars in cell & developmental biology · 2022
    Review
  9. Deletion of Fibroblast growth factor 9 globally and in skeletal muscle results in enlarged tuberosities at sites of deltoid tendon attachments.Developmental dynamics : an official publication of the American Association of Anatomists · 2021
    Article
  10. Development and maintenance of tendons and ligaments.Development (Cambridge, England) · 2021
    Review
  11. Making and shaping endochondral and intramembranous bones.Developmental dynamics : an official publication of the American Association of Anatomists · 2021
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shai EyalWeizmann Institute of Science, Department of Molecular Genetics, Rehovot 76100, Israel.ORCID 0000-0001-8131-8077
Shiri KultWeizmann Institute of Science, Department of Molecular Genetics, Rehovot 76100, Israel.
Sarah RubinWeizmann Institute of Science, Department of Molecular Genetics, Rehovot 76100, Israel.
Sharon KriefWeizmann Institute of Science, Department of Molecular Genetics, Rehovot 76100, Israel.
Neta FelsenthalWeizmann Institute of Science, Department of Molecular Genetics, Rehovot 76100, Israel.
Kyriel M PineaultUniversity of Wisconsin-Madison, Department of Cell & Regenerative Biology, Madison, WI 53705, USA.
Dena LeshkowitzWeizmann Institute of Science, Department of Life Sciences Core Facilities, Rehovot 76100, Israel.
Tomer-Meir SalameWeizmann Institute of Science, Department of Life Sciences Core Facilities, Rehovot 76100, Israel.
Yoseph AddadiWeizmann Institute of Science, Department of Life Sciences Core Facilities, Rehovot 76100, Israel.
Deneen M WellikUniversity of Wisconsin-Madison, Department of Cell & Regenerative Biology, Madison, WI 53705, USA.ORCID 0000-0003-4078-8560
Elazar ZelzerWeizmann Institute of Science, Department of Molecular Genetics, Rehovot 76100, Israel eli.zelzer@weizmann.ac.il.ORCID 0000-0002-1584-6602

Funding

Tendon Enthesis Development and RegenerationR01AR055580 · NIAMS · WASHINGTON UNIVERSITY · PI THOMOPOULOS, STAVROS · 2009 to 2019
$4.0M
Role of Hox Genes in Integration of the Musculoskeletal System in Development R01AR061402 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI WELLIK, DENEEN M · 2011 to 2021
$3.3M
NIAMS NIH HHS R01 AR055580NIAMS NIH HHS R01 AR061402
6 · The paper itself

Abstract

Bone protrusions provide stable anchoring sites for ligaments and tendons and define the unique morphology of each long bone. Despite their importance, the mechanism by which superstructures are patterned is unknown. Here, we identify components of the genetic program that control the patterning of

Indexed as

Genes, DevelopmentalAnimalsBasic Helix-Loop-Helix ProteinsBone and BonesBone DevelopmentEmbryo, MammalianFemaleGene Expression Regulation, DevelopmentalHomeodomain ProteinsLigamentsMaleMiceMice, TransgenicOrgan SpecificityPre-B-Cell Leukemia Transcription Factor 1PregnancyBasic Helix-Loop-Helix ProteinsHomeodomain ProteinsPbx1 protein, mousePre-B-Cell Leukemia Transcription Factor 1Scx protein, mouseSox9 protein, mouseSOX9 Transcription FactorCartilageGli3HoxModularityMorphologyMousePatterningPbxScleraxisSox9Superstructure

Identifiers

PMID31221640
PMCPMC6679367

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.