Evidence map›Paper›PMID 31221635›Full record

ArticleAJNR. American journal of neuroradiology2019

Brain Tumor-Enhancement Visualization and Morphometric Assessment: A Comparison of MPRAGE, SPACE, and VIBE MRI Techniques.

L Danieli, G C Riccitelli, D Distefano, E Prodi, E Ventura, A Cianfoni, A Kaelin-Lang, M Reinert, E Pravatà

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 2 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.

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  5. Clinical and MRI factors influencing interobserver delineation variability of brain metastases before stereotactic radiotherapy.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

L DanieliFrom the Departments of Neuroradiology (L.D., D.D., E.P., E.V., A.C., E.P.).ORCID 0000-0002-3098-9695
G C RiccitelliNeurology (G.C.R., A.K.-L.).ORCID 0000-0002-1202-5534
D DistefanoFrom the Departments of Neuroradiology (L.D., D.D., E.P., E.V., A.C., E.P.).ORCID 0000-0002-7591-1314
E ProdiFrom the Departments of Neuroradiology (L.D., D.D., E.P., E.V., A.C., E.P.).ORCID 0000-0003-1200-0465
E VenturaFrom the Departments of Neuroradiology (L.D., D.D., E.P., E.V., A.C., E.P.).ORCID 0000-0002-9029-6516
A CianfoniFrom the Departments of Neuroradiology (L.D., D.D., E.P., E.V., A.C., E.P.).ORCID 0000-0001-9333-4912
A Kaelin-LangNeurology (G.C.R., A.K.-L.).ORCID 0000-0002-5249-073X
M ReinertNeurosurgery (M.R.), Neurocenter of Southern Switzerland, Lugano, Switzerland.ORCID 0000-0002-0971-9543
E PravatàFrom the Departments of Neuroradiology (L.D., D.D., E.P., E.V., A.C., E.P.) emanuele.pravata@eoc.ch.ORCID 0000-0002-5225-2993
S.P.E.C.I.E.S. · USAnna Needs Neuroblastoma Answers · USLaboratory for Biomedical Neurosciences · CHUniversity of Bern · CHVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposePostgadolinium MR imaging is crucial for brain tumor diagnosis and morphometric assessment. We compared brain tumor enhancement visualization and the "target" object morphometry obtained with the most commonly used 3D MR imaging technique, MPRAGE, with 2 other routinely available techniques: sampling perfection with application-optimized contrasts by using different flip angle evolutions (SPACE) and volumetric interpolated brain examination (VIBE). MATERIALS AND

methodsFifty-four contrast-enhancing tumors (38 gliomas and 16 metastases) were assessed using MPRAGE, VIBE, and SPACE techniques randomly acquired after gadolinium-based contrast agent administration on a 3T scanner. Enhancement conspicuity was assessed quantitatively by calculating the contrast rate and contrast-to-noise ratio, and qualitatively, by consensus visual comparative ratings. The total enhancing tumor volume and between-sequence discrepancy in the margin delineation were assessed on the corresponding 3D target objects contoured with a computer-assisted software for neuronavigation. The Wilcoxon signed rank and Pearson χ

resultsCompared with MPRAGE, both SPACE and VIBE obtained higher contrast rate, contrast-to-noise ratio, and visual conspicuity ratings in both gliomas and metastases (

conclusionsSuperior conspicuity for brain tumor enhancement can be achieved using SPACE and VIBE techniques, compared with MPRAGE. Discrepancies were also detected when assessing target object size and morphology, with SPACE providing more accurate estimates.

Indexed as

AdultAgedBrain NeoplasmsContrast MediaFemaleGliomaHumansImage Interpretation, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingContrast Media

Identifiers

PMID31221635
PMCPMC7048542
OpenAlexW2950654854

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.