SynthesisBritish journal of anaesthesia2019
Systematic review of analgesics and dexamethasone for post-tonsillectomy pain in adults.
Synthesis in British journal of anaesthesia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05435833 (Ultrasound-Guided Submandibular Parapharyngeal Glossopharyngeal Nerve Block for Post -Tonsillectomy Pain Relief in Adults. A Prospective Randomized Study), which is not on this map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Ultrasound-Guided Submandibular Parapharyngeal Glossopharyngeal Nerve Block for Post -Tonsillectomy Pain Relief in Adults. A Prospective Randomized Study
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- PROSPECT guideline for tonsillectomy: systematic review and procedure-specific postoperative pain management recommendations.Anaesthesia · 2021Pooled it
- Efficacy and Safety of Topical Sucralfate for Post-Tonsillectomy Pain in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-facialePooled it
- Comparing the efficacy of combining ketorolac and Paracetamol (Acetaminophen) with Paracetamol alone on postoperative pain after laminectomy. A double-blinded randomized clinical trial.BMC anesthesiology · 2025Trial
- Tonsillectomy compared with conservative management in patients over 16 years with recurrent sore throat: the NATTINA RCT and economic evaluation.Health technology assessment (Winchester, England) · 2023Trial
- Dexamethasone as additive of local infiltration analgesia reduces opioids consumption after simultaneous bilateral total hip or knee arthroplasty: a randomized controlled double-blind trial.Journal of orthopaedic surgery and research · 2023Trial
- Can probiotic gargles reduce post-tonsillectomy morbidity in adult patients? A pilot, triple-blind, randomised, controlled trial and feasibility study.The Journal of laryngology and otology · 2023Trial
- Role of Pain in Adults Undergoing Soft Tissue and Maxillomandibular Advancement Surgery for Obstructive Sleep Apnea.Laryngoscope investigative otolaryngology · 2025Article
- Article
- Procedure-specific pain trajectories and process quality in elective otolaryngology surgery: a single-center cohort study.Frontiers in medicine · 2025Article
- International Consensus Statement on Obstructive Sleep Apnea.International forum of allergy & rhinology · 2023Review
- Postoperative systemic inflammatory dysregulation and corticosteroids: a narrative review.Anaesthesia · 2023Review
- Effect of Oral Prednisolone on Pain after Tonsillectomy with Sutures: A Randomized Clinical Trial.Advanced biomedical research · 2023Article
- Treatment of recurrent acute tonsillitis-a systematic review and clinical practice recommendations.Frontiers in surgery · 2023Review
- Effect of aminophylline, ketamine and paracetamol on pain intensity after deep vitrectomy surgery.International journal of physiology, pathophysiology and pharmacology · 2022Article
- Effect of Perineural Dexamethasone with Ropivacaine in Continuous Serratus Anterior Plane Block for Postoperative Analgesia in Patients Undergoing Video-Assisted Thoracoscopic Surgery.Journal of pain research · 2022Article
- Multimodal Analgesia With Long-Acting Dinalbuphine Sebacate Plus Transversus Abdominis Plane Block for Perioperative Pain Management in Bariatric Surgery: A Case Report.Frontiers in pharmacology · 2021Article
- A review of dexamethasone as an adjunct to adenotonsillectomy in the pediatric population.Journal of anesthesia · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntense pain can last several days after tonsillectomy. It is often undertreated and improved analgesic strategies that can be safely used at home are needed.
methodsWe conducted a systematic review and meta-analysis on the effectiveness of systemic medications used for post-tonsillectomy pain in adult and adolescent (13 yr old) patients. Studies were identified from PubMed, the Cochrane Library, and by hand searching reference lists from studies and review articles. Randomised, double-blind, placebo-controlled studies reporting on pain intensity or use of rescue analgesia were included.
resultsTwenty-nine randomised controlled trials representing 1816 subjects met the inclusion criteria. Follow-up time was ≤24 h in 15 studies, in which the majority were taking nonsteroidal anti-inflammatory drugs. Thirteen studies were suitable for meta-analysis. In pooled analysis, paracetamol, dexamethasone, and gabapentinoids reduced pain intensity on the day of operation. In individual studies, ketoprofen, ibuprofen, lornoxicam, parecoxib, rofecoxib, indomethacin and dextromethorphan reduced pain intensity, need for rescue analgesics, or both on the day of operation. Oral celecoxib for 2 postoperative weeks or i.v. ketamine on the day of operation were not effective at the studied doses. Dexamethasone in multiple doses provided analgesia beyond 1 postoperative day. Pain was moderate to strong in both study and control groups during the first postoperative week.
conclusionsSingle analgesics and dexamethasone provide only a weak to moderate effect for post-tonsillectomy pain on the day of operation and thus a multimodal analgesic strategy is recommended. Short follow-up times and clinical heterogeneity of studies limit the usefulness of results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.