ArticleTrials2019
PRevention of INCisional hernia after liver transplantation (PRINC trial): study protocol for a randomized controlled trial.
Article in Trials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Hernia Correction After Liver Transplantation Using Nonvascularized Fascia.Transplantation direct · 2024Article
- Prophylactic Mesh Augmentation of Midline Closure in Patients Undergoing Resection for Upper Gastrointestinal Cancer Reduces the Rate of Incisional Hernia: Results of a Case-Series Study.Journal of abdominal wall surgery : JAWS · 2024Article
- Incisional Hernia Following Open Pancreaticoduodenectomy: Incidence and Risk Factors at a Tertiary Care Centre.Current oncology (Toronto, Ont.) · 2023Article
- Fully resorbable poly-4-hydroxybutyrate (P4HB) mesh for soft tissue repair and reconstruction: A scoping review.Frontiers in surgery · 2023Article
- Outcomes of Bariatric Surgery Before, During, and After Solid Organ Transplantation.Obesity surgery · 2022Article
- Length of stay and surgical site complications are not increased after elective incisional hernia in patients with a history of solid organ transplantation.Surgical endoscopy · 2022Article
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncisional hernia is a common complication after liver transplantation with an incidence of 5 to 46%. Concerning non-transplant patients, a recently published meta-analysis describes a reduction of the incidence of incisional hernia of up to 85% due to prophylactic mesh replacement in elective, midline laparotomy. The aim of our study is to show a reduction of the incidence of incisional hernia after liver transplantation with minimal risk for complication. METHODS/
designThis is an unblinded, randomized controlled trial comparing time to incisional hernia over a period of 12 months between patients undergoing liver transplantation and standardized abdominal closure with or without prophylactic placement of Phasix™ (Bard - Davol Inc., Warwick, RI, USA) mesh in an onlay position. As we believe that the mesh intervention is superior to the standard procedure in reducing the incidence of hernia, this is a superiority trial. DISCUSSION: The high risk for developing incisional hernia following liver transplantation might be reduced by prophylactic mesh placement. Immunosuppressed patients are at high risk for developing surgical-site infections. We chose a mesh which has anti-inflammatory properties and is fully resorbed after 18 months.
trial registrationClinicalTrials.gov, ID: 03222102 . Registered retrospectively on 17 July 2018. Protocol version 1.4, 7 October 2018.
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