Evidence map›Paper›PMID 31221179›Full record

ArticleMolecular brain2019

Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice.

Hye Lim Cha, Jung-Mi Choi, Huy-Hyen Oh, Narayan Bashyal, Sung-Soo Kim, Lutz Birnbaumer, Haeyoung Suh-Kim

Open access · goldAbstract read
In one paragraph

Article in Molecular brain, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Phenotypic Heterogeneity in Genetic and Acquired Pediatric Cerebellar Disorders.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  2. CB1R activates the epilepsy-associated protein Go to regulate neurotransmitter release and synaptic plasticity in the cerebellum.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  3. Article
  4. Observational
  5. Article
  6. Article
  7. Exploring pharmacological inhibition of GBritish journal of pharmacology · 2022
    Article
  8. Article
  9. Article
  10. Review
  11. Reduced CaFrontiers in neuroscience · 2022
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Hye Lim ChaDepartments of Anatomy, Ajou University School of Medicine, Woldcup-ro 164, Yeongtong-gu, Suwon, 16499, South Korea.
Jung-Mi ChoiDepartments of Anatomy, Ajou University School of Medicine, Woldcup-ro 164, Yeongtong-gu, Suwon, 16499, South Korea.
Huy-Hyen OhDepartments of Anatomy, Ajou University School of Medicine, Woldcup-ro 164, Yeongtong-gu, Suwon, 16499, South Korea.
Narayan BashyalDepartments of Anatomy, Ajou University School of Medicine, Woldcup-ro 164, Yeongtong-gu, Suwon, 16499, South Korea.
Sung-Soo KimDepartments of Anatomy, Ajou University School of Medicine, Woldcup-ro 164, Yeongtong-gu, Suwon, 16499, South Korea.
Lutz BirnbaumerNeurobiology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, 27709, NC, USA.
Haeyoung Suh-KimDepartments of Anatomy, Ajou University School of Medicine, Woldcup-ro 164, Yeongtong-gu, Suwon, 16499, South Korea. hysuh@ajou.ac.kr.ORCID 0000-0001-8175-1209
Ajou University · KRPontificia Universidad Católica Argentina · AR

Funding

Transmembrane Signaling MechanismsZ01ES101643 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI BIRNBAUMER, LUTZ · 2003 to 2008
$5.1M
Intramural NIH HHS Z01 ES101643
6 · The paper itself

Abstract

G

Indexed as

Gene DeletionAnimalsCerebral CortexDendritesGTP-Binding Protein alpha Subunits, Gi-GoMice, Inbred C57BLNeuronsPresynaptic TerminalsPurkinje CellsRNA, MessengerSynaptic MembranesGNAO1 protein, mouseGTP-Binding Protein alpha Subunits, Gi-GoRNA, MessengerCerebellar developmentCerebellumClimbing fiberGo alpha subunit (GαoGTP-binding protein alpha subunit of Go)HypoplasiaPurkinje cellSynaptic boutons

Identifiers

PMID31221179
PMCPMC6585000
OpenAlexW2950425598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.