ArticleBMC nephrology2019
Mercury-associated glomerulonephritis: a retrospective study of 35 cases in a single Chinese center.
Article in BMC nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Associations Between Toxic Metal Exposure and Childhood Nephrotic Syndrome.Kidney international reports · 2026Article
- Environmental Pollution and Its Impact on Kidney Diseases: A Comprehensive Review of Current Evidence.Life (Basel, Switzerland) · 2026Review
- Article
- Snow White's tale in nephrology: the emerging threat of skin-whitening creams on kidney health.Clinical kidney journal · 2025Review
- Case Report: Nephrotic syndrome caused by mercury poisoning due to freckle-removing cream.Frontiers in medicine · 2025Article
- Complementary and Alternative Medicine Use and Glomerular Disease: A Contemporary Case Series.Kidney medicine · 2024Article
- Nephrotic Syndrome Associated With Heavy Metals Exposure: A Case Report and Literature Review.Cureus · 2024Article
- Can Corticosteroids be Used as a First-Line Agent for Mercury-Related Glomerular Diseases?Kidney international reports · 2023Article
- Clinicopathological features and long-term prognosis of glomerular diseases associated with mercury-containing cosmetics.Journal of nephrology · 2023Article
- A case of chronic mercury poisoning associated nephrotic syndrome, abdominal pain, and neuropsychiatric symptoms.Renal failure · 2023Article
- What Can Mercury Teach Us About Membranous Nephropathy and Minimal Change Disease?Kidney international reports · 2022Article
- Toxic effects of selected trace elements contained in make-ups on female university students in Nigeria.Environmental monitoring and assessment · 2021Article
- Unveiling the Features of Mercury-Associated Minimal Change Disease: Comparison with Primary Minimal Change Disease.Kidney diseases (Basel, Switzerland) · 2021Article
- Membranous Nephropathy Associated With Indigenous Indian Medications Containing Heavy Metals.Kidney international reports · 2020Article
- An unusual cause of nephrotic syndrome in a 10-year-old girl: Answers.Pediatric nephrology (Berlin, Germany) · 2020Article
- Mercury in natural health products as a cause of membranous nephropathy.Proceedings (Baylor University. Medical Center) · 2020Article
- Nell1 as Target Antigen for Mercury Related Membranous Nephropathy: A Case Report.Indian journal of nephrologyArticle
- Nerve Epidermal Growth Factor-Like 1 Protein (NELL-1) Expression in Mercury-Related Membranous Nephropathy: Is It a True Association or a Chance Occurrence?Indian journal of nephrologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLong-term exposure of mercury may induce glomerulonephritis. Clinical and pathological features of mercury-associated glomerulonephritis are not fully clear. This study retrospectively analyzed 35 cases of mercury-associated glomerulonephritis in a single Chinese center.
methodsThirty-five patients of mercury-associated glomerulonephritis were enrolled. Clinical data on diagnosis and during follow-up were collected. Plasma anti-phospholipase A2 receptor (PLA2R) antibody, glomerular PLA2R and glomerular IgG subclasses deposition were detected in the cases with membranous nephropathy (MN).
resultsMercury exposure was caused by skin lighting cream (20 patients), mercury-containing pills (9 patients), hair-dyeing agents (4 patients), and unidentified reasons (2 patients). All patients presented with proteinuria and normal renal function. The median of urinary protein was 4.6 (range 1.6~19.7) g/24 h. Twenty-two patients (62.9%) had nephrotic syndrome. Renal histopathology showed minimal change disease (MCD) in 21 patients (60.0%), MN in 13 (37.1%) and focal segmental glomerular sclerosis (FSGS) in 1 patient (2.9%). The proportion of MCD increased along with urinary mercury concentration (P = 0.024). In 13 cases of MN, all patients were negative for plasma anti-PLA2R antibody and glomerular PLA2R antigen. IgG1 (61.5%) and IgG4 (46.2%) deposits were noted along the glomerular capillary loops. Among the 16 patients received mercury detoxification monotherapy, 14 patients received 4.5 ± 2.8 (range 1~12) rounds of regimen and achieved complete remission in 4.5 (range 0.3~23.0) months, 2 patients stayed no remission.
conclusionsMCD was the most common pathological type of mercury-associated glomerulonephritis, followed by MN. The proportion of MCD increased along with the increase of urinary mercury concentration. Most patients could achieve complete remission after mercury detoxification.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.