Evidence map›Paper›PMID 31221051›Full record

ArticleLupus2019

Increased blood pressure visit-to-visit variability in patients with systemic lupus erythematosus: association with inflammation and comorbidity burden.

T Reese, A L Dickson, M M Shuey, J S Gandelman, A Barnado, K A Barker, J E Neal, O A Khan, W D Dupont, C M Stein and 1 more

Abstract read
In one paragraph

Article in Lupus, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Short-Term Variability of Both Brachial and Aortic Blood Pressure is Increased in Patients with Immune-mediated Chronic Inflammation.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2024
    Article
  6. Commentary on "Short-Term Variability of Both Brachial and Aortic Blood Pressure is Increased in Patients with Immune-Mediated Chronic Inflammation".High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2024
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

T Reese1 Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID https://orcid.org/0000-0002-4348-969X
A L Dickson1 Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
M M Shuey1 Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
J S Gandelman2 Vanderbilt University School of Medicine, Nashville, TN, USA.
A Barnado1 Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID https://orcid.org/0000-0002-9573-4335
K A Barker1 Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
J E Neal3 Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
O A Khan3 Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
W D Dupont3 Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
C M Stein1 Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
C P Chung1 Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Funding

VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Building Interdisciplinary Research Careers in Women's HealthK12HD043483 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARTMANN, KATHERINE E, MAJOR, AMY S · 2002 to 2023
$10.3M
A Personalized Medicine Approach to Improve the Prediction of Azathioprine ToxicityR01GM126535 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CHUNG, CECILIA PILAR · 2018 to 2022
$2.3M
Using the electronic health record to risk-stratify patients with systemic lupus erythematosusK08AR072757 · NIAMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BARNADO, APRIL LYNN · 2018 to 2022
$817k
Drug-Drug Interactions and Preventable Adverse Events in RheumatologyK23AR064768 · NIAMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CHUNG, CECILIA PILAR · 2013 to 2016
$531k
Association of CYP4A11 Variants with Resistant HypertensionF31DK108444 · NIDDK · VANDERBILT UNIVERSITY · PI SHUEY, MEGAN MARIE · 2016 to 2017
$57k
NCATS NIH HHS UL1 TR000445NCRR NIH HHS UL1 RR024975NIAMS NIH HHS K08 AR072757NIAMS NIH HHS K23 AR064768NICHD NIH HHS K12 HD043483NIDDK NIH HHS F31 DK108444NIGMS NIH HHS R01 GM126535
6 · The paper itself

Abstract

backgroundBlood pressure visit-to-visit variability is a novel risk factor for deleterious long-term cardiac and renal outcomes in the general population. We hypothesized that patients with systemic lupus erythematosus (SLE) have greater blood pressure visit-to-visit variability than control subjects and that blood pressure visit-to-visit variability is associated with a higher comorbidity burden.

methodsWe studied 899 patients with SLE and 4172 matched controls using de-identified electronic health records from an academic medical center. We compared blood pressure visit-to-visit variability measures in patients with SLE and control subjects and examined the association between blood pressure visit-to-visit variability and patients' characteristics.

resultsPatients with SLE had higher systolic blood pressure visit-to-visit variability 9.7% (7.8-11.8%) than the control group 9.2% (7.4-11.2%),

conclusionPatients with SLE had higher blood pressure visit-to-visit variability than controls, and this increased blood pressure visit-to-visit variability was associated with greater Charlson comorbidity scores, several clinical characteristics and immunosuppressant medications. In particular, hydroxychloroquine prescription was associated with lower blood pressure visit-to-visit variability.

Indexed as

ComorbidityAdrenal Cortex HormonesAdultBlood PressureCase-Control StudiesCyclophosphamideDatabases, FactualFemaleHumansHydroxychloroquineHypertensionInflammationLogistic ModelsLupus Erythematosus, SystemicMaleMiddle AgedAdrenal Cortex HormonesCyclophosphamideHydroxychloroquineMycophenolic Acidcardiovascular diseaserenal lupusSystemic lupus erythematosus

Identifiers

PMID31221051
PMCPMC6613390

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.