Evidence map›Paper›PMID 31220651›Full record

ArticleVirology2019

The role of cell surface expression of influenza virus neuraminidase in induction of human lymphocyte apoptosis.

Joan E Nichols, Jean A Niles, Elisa H Fleming, Norbert J Roberts

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Analysis of clinical characteristics and risk factors for death due to severe influenza in children.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
    Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Joan E NicholsDivision of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch at Galveston, Texas, USA; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Texas, USA.
Jean A NilesDivision of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch at Galveston, Texas, USA.
Elisa H FlemingDivision of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch at Galveston, Texas, USA; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Texas, USA.
Norbert J RobertsDivision of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch at Galveston, Texas, USA; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Texas, USA; Division of Infectious Diseases and Immunology, Department of Medicine, New York University School of Medicine, New York, NY, USA. Electronic address: norbert.roberts@nyulangone.org.
The University of Texas Medical Branch at Galveston · US

Funding

EMERGING AND TROPICAL INFECTIOUS DISEASEST32AI007526 · NIAID · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI SOONG, LYNN · 1997 to 2025
$3.1M
NIAID NIH HHS T32 AI007526
6 · The paper itself

Abstract

The immunopathological mechanisms as well as the role played by influenza A virus infection of human leukocytes and induction of apoptosis have not been fully elucidated. We confirm here that the percentage of cells that are infected is less than the percent of apoptotic cells. Depletion of monocytes/macrophages and depletion of cells expressing influenza neuraminidase from the cultures after exposure to virus decreased lymphocyte apoptosis. Treatment of virus-exposed leukocyte cultures with anti-neuraminidase antibodies but not with anti-hemagglutinin antibodies, reduced lymphocyte production of active caspase-3 and induction of apoptosis. Different strains of virus induced different levels of apoptosis. Variations in induction of apoptosis correlated with production and expression of viral neuraminidase by infected leukocytes. The data suggest that cell surface expression of neuraminidase plays an important role in the induction of apoptosis in human lymphocytes. The benefit, or cost, to the host of lymphocyte apoptosis warrants continued investigation.

Indexed as

ApoptosisAnimalsCaspase 3Cell MembraneHost-Pathogen InteractionsHumansInfluenza A virusInfluenza, HumanLymphocytesNeuraminidaseViral ProteinsCaspase 3NA protein, influenza A virusNeuraminidaseViral ProteinsApoptosisHuman lymphocytesHuman macrophagesHuman monocytesInfluenza virusNeuraminidase

Identifiers

PMID31220651
PMCPMC6614004
OpenAlexW2951112566

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.