Evidence map›Paper›PMID 31220449›Full record

ArticleThe American journal of pathology2019

The Protective Role of Natriuretic Peptide Receptor 2 against High Salt Injury in the Renal Papilla.

George J Dugbartey, Breandan Quinn, Lingfeng Luo, Deanne M Mickelsen, Sara K Ture, Craig N Morrell, Jan Czyzyk, Marvin M Doyley, Chen Yan, Bradford C Berk and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Natriuretic Peptide Receptor 2 Locus Contributes to Carotid Remodeling.Journal of the American Heart Association · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

George J DugbarteyAab Cardiovascular Research Institute, Hajim School of Engineering and Applied Sciences, University of Rochester, Rochester, New York.
Breandan QuinnAab Cardiovascular Research Institute, Hajim School of Engineering and Applied Sciences, University of Rochester, Rochester, New York.
Lingfeng LuoAab Cardiovascular Research Institute, Hajim School of Engineering and Applied Sciences, University of Rochester, Rochester, New York.
Deanne M MickelsenAab Cardiovascular Research Institute, Hajim School of Engineering and Applied Sciences, University of Rochester, Rochester, New York.
Sara K TureAab Cardiovascular Research Institute, Hajim School of Engineering and Applied Sciences, University of Rochester, Rochester, New York.
Craig N MorrellAab Cardiovascular Research Institute, Hajim School of Engineering and Applied Sciences, University of Rochester, Rochester, New York.
Jan CzyzykDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota.
Marvin M DoyleyDepartment of Electrical and Computer Engineering, Hajim School of Engineering and Applied Sciences, University of Rochester, Rochester, New York.
Chen YanAab Cardiovascular Research Institute, Hajim School of Engineering and Applied Sciences, University of Rochester, Rochester, New York.
Bradford C BerkAab Cardiovascular Research Institute, Hajim School of Engineering and Applied Sciences, University of Rochester, Rochester, New York; Department of Medicine, Neurorestoration Institute, Hajim School of Engineering and Applied Sciences, University of Rochester, Rochester, New York. Electronic address: bradford_berk@urmc.rochester.edu.
Vyacheslav A KorshunovAab Cardiovascular Research Institute, Hajim School of Engineering and Applied Sciences, University of Rochester, Rochester, New York. Electronic address: slava_korshunov@urmc.rochester.edu.
University of Rochester · USUniversity of Minnesota · US

Funding

GENETICS OF VASCULAR REMODELING IN HYPERTENSIONR01HL062826 · NHLBI · UNIVERSITY OF ROCHESTER · PI BERK, BRADFORD C · 1999 to 2013
$4.2M
PDE10A Regulation and Function in Cardiovascular DiseaseR01HL134910 · NHLBI · UNIVERSITY OF ROCHESTER · PI BERK, BRADFORD C, YAN, CHEN · 2017 to 2020
$2.1M
NHLBI NIH HHS R01 HL062826NHLBI NIH HHS R01 HL134910
6 · The paper itself

Abstract

Mutations in natriuretic peptide receptor 2 (Npr2) gene cause a rare form of short-limbed dwarfism, but its physiological effects have not been well studied. Human and mouse genetic data suggest that Npr2 in the kidney plays a role in salt homeostasis. Herein, we described anatomic changes within renal papilla of Npr2 knockout (Npr2

Indexed as

Acute Kidney InjuryAnimalsAtrial Natriuretic Factor Receptor BFemaleHumansHypertensionKidney MedullaMaleMiceMice, KnockoutReceptors, Atrial Natriuretic FactorSodium ChlorideAtrial Natriuretic Factor Receptor BReceptors, Atrial Natriuretic FactorSodium Chloride

Identifiers

PMID31220449
PMCPMC6724224
OpenAlexW2953357769

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.