Evidence map›Paper›PMID 31220424›Full record

ReviewGastroenterology2019

Fecal Microbial Transplantation for Diseases Beyond Recurrent Clostridium Difficile Infection.

Geert R D'Haens, Christian Jobin

Registry-linked trialAbstract readReview
In one paragraph

Review in Gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06992453 (Disentangling Microbiome Engraftment by Multi-omics of the Gut Ecosystem During Fecal Transplant), which is not on this map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06992453 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Disentangling Microbiome Engraftment by Multi-omics of the Gut Ecosystem During Fecal Transplant

TypeinterventionalSponsorCatholic University of the Sacred HeartRan2026 to 2029Enrolled90ConditionsRecurrent C. Difficile (rCDI), Ulcerative Colitis (UC), Metabolic Syndrome (MetS)ArmsFecal microbiota transplantation (FMT)
3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Development a novel in silico mRNA vaccine against Clostridium difficile.Journal, genetic engineering & biotechnology · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Neutrophils: from IBD to the gut microbiota.Nature reviews. Gastroenterology & hepatology · 2024
    Review
  17. Review
  18. Gut microbes · 2023
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Geert R D'HaensDepartment of Gastroenterology, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Christian JobinDepartments of Medicine, Anatomy and Cell Biology, and Infectious Diseases and Immunology, University of Florida, Gainesville, Florida. Electronic address: Christian.Jobin@medicine.ufl.edu.

Funding

The role of klebsiella pneumonia-derived colibactin in colitis-associated colon cancerR01DK073338 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JOBIN, CHRISTIAN · 2007 to 2023
$5.4M
Impact of microbiota-mediated biotransformation of black tea polyphenolsR01AT008623 · NCCIH · UNIVERSITY OF FLORIDA · PI JOBIN, CHRISTIAN, SANG, SHENGMIN · 2015 to 2019
$2.1M
Mechanism by which H2S-producing bacteria influence development of colorectal cancerR21CA195226 · NCI · UNIVERSITY OF FLORIDA · PI JOBIN, CHRISTIAN · 2016 to 2017
$367k
NCCIH NIH HHS R01 AT008623NCI NIH HHS R21 CA195226NIDDK NIH HHS R01 DK073338
6 · The paper itself

Abstract

As microbiome research has moved from associative to mechanistic studies, the activities of specific microbes and their products have been investigated in the development of inflammatory bowel diseases, cancer, metabolic syndrome, and neuropsychiatric disorders. Findings from microbiome research have already been applied to the clinic, such as in fecal microbiota transplantation for treatment of recurrent Clostridium difficile infection. We review the evidence for associations between alterations in the intestinal microbiome and gastrointestinal diseases and findings from clinical trials of fecal microbiota transplantation. We discuss opportunities for treatment of other diseases with fecal microbiota transplantation, based on findings from small clinical and preclinical studies.

Indexed as

Fecal Microbiota TransplantationGastrointestinal MicrobiomeAnimalsCentral Nervous System DiseasesClostridium InfectionsGastrointestinal DiseasesHumansInflammationRecurrenceTreatment OutcomeCancerFecal Microbiota TransplantationInflammationMetabolic SyndromeMicrobial Manipulation

Identifiers

PMID31220424
PMCPMC7179251

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.