Evidence map›Paper›PMID 31220336›Full record

SynthesisJournal of the American Geriatrics Society2019

Incidence of Dementia and Alzheimer Disease Over Time: A Meta-Analysis.

Sujuan Gao, Heather N Burney, Chris M Callahan, Christianna E Purnell, Hugh C Hendrie

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of the American Geriatrics Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 2 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 96 citations in OpenAlex.

  1. Pooled it
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  3. Incidence of dementia and mild cognitive impairment in two Indigenous Bolivian cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Sujuan GaoDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana.
Heather N BurneyDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana.
Chris M CallahanIndiana University Center for Aging Research, Indianapolis, Indiana.
Christianna E PurnellRegenstrief Institute, Inc, Indianapolis, Indiana.
Hugh C HendrieIndiana University Center for Aging Research, Indianapolis, Indiana.
Indiana University – Purdue University Indianapolis · USRegenstrief Institute · USIndiana University School of Medicine

Funding

Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3M
Longitudinal interactive vascular exposure and Alzheimer's DiseaseR01AG045350 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI GAO, SUJUAN · 2014 to 2016
$925k
NIA NIH HHS P30 AG010133NIA NIH HHS R01 AG045350NIH HHS P30 AG010133NIH HHS RO1 AG045350
6 · The paper itself

Abstract

BACKGROUND/

objectivesPopulation-based incidence estimates of dementia and Alzheimer disease (AD) provide important information for public health policy and resource allocation. We conducted a meta-analysis of published studies that reported age-specific incidence rates of dementia and AD to determine whether dementia and AD incidence rates are changing over time.

designPubMed and MEDLINE were searched for publications through June 30, 2017, using key words "dementia", "Alzheimer", and "incidence." Inclusion criteria for the meta-analysis are: (1) population-based studies using personal interviews and direct examinations of the study subjects, (2) standardized clinical diagnosis criteria, (3) reporting age-specific incidence rates, (4) published in English, and (5) sample size of 500 or greater and length of follow-up of 2 years or greater. Mixed-effects models were used to determine the association between birth year and incidence rates. MEASUREMENTS: Age-specific dementia/AD incidence rates and their standard errors reported in each study.

resultsThirty-eight articles with 53 cohorts on dementia incidence and 31 articles with 35 cohorts on AD incidence met the inclusion criteria. There were significant associations between later birth years and decreased dementia incidence rates in all three age groups (65-74, 75-84, and 85 years and older). There were no significant associations between birth year and AD incident rates in any of the three age groups. In particular, AD incidence rates reported from Western countries stayed steady in all age groups, while studies in non-Western countries showed significantly increased AD incidence rates for the 65 to 74 years age group (odds ratio = 2.78; P = .04), but a nonsignificant association for the 75 to 84 or 85 years and older groups.

conclusionDementia incidence declined over the past four decades, but AD incidence did not decline. Further research, especially from non-Western countries, is needed to elucidate the mechanism underlying the trends in dementia and AD incidence over time.

Indexed as

AgedAged, 80 and overAge FactorsAlzheimer DiseaseDementiaHumansAlzheimer diseasedementiaincidencetrend

Identifiers

PMID31220336
PMCPMC6612587
OpenAlexW2952223503

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.