Evidence map›Paper›PMID 31220300›Full record

ArticleJournal of molecular cell biology2019

Rheb promotes brown fat thermogenesis by Notch-dependent activation of the PKA signaling pathway.

Wen Meng, Xiuci Liang, Ting Xiao, Jing Wang, Jie Wen, Hairong Luo, Jianhui Teng, Yanquan Fei, Qinghai Zhang, Bilian Liu and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. mTORC1 in energy expenditure: consequences for obesity.Nature reviews. Endocrinology · 2024
    Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Wen MengDepartment of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Xiuci LiangDepartment of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Ting XiaoDepartment of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Jing WangDepartment of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Jie WenDepartment of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Hairong LuoDepartment of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Jianhui TengDepartment of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Yanquan FeiDepartment of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Qinghai ZhangDepartment of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Bilian LiuDepartment of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Fang HuDepartment of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Juli BaiDepartment of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Meilian LiuDepartment of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Zhiguang ZhouDepartment of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Feng LiuDepartment of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Second Xiangya Hospital of Central South University · CNCentral South University · CN

Funding

The Role of Adiponectin in Regulating Group 2 Innate Lymphoid Cells and Browning in FatR01DK110439 · NIDDK · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI LIU, MEILIAN · 2017 to 2021
$1.8M
NIDDK NIH HHS R01 DK110439
6 · The paper itself

Abstract

Increasing brown and beige fat thermogenesis have an anti-obesity effect and thus great metabolic benefits. However, the molecular mechanisms regulating brown and beige fat thermogenesis remain to be further elucidated. We recently found that fat-specific knockout of Rheb promoted beige fat thermogenesis. In the current study, we show that Rheb has distinct effects on thermogenic gene expression in brown and beige fat. Fat-specific knockout of Rheb decreased protein kinase A (PKA) activity and thermogenic gene expression in brown adipose tissue of high-fat diet-fed mice. On the other hand, overexpression of Rheb activated PKA and increased uncoupling protein 1 expression in brown adipocytes. Mechanistically, Rheb overexpression in brown adipocytes increased Notch expression, leading to disassociation of the regulatory subunit from the catalytic subunit of PKA and subsequent PKA activation. Our study demonstrates that Rheb, by selectively modulating thermogenic gene expression in brown and beige adipose tissues, plays an important role in regulating energy homeostasis.

Indexed as

Signal TransductionThermogenesisAdipocytesAdipose Tissue, BrownAdipose Tissue, WhiteAnimalsCyclic AMP-Dependent Protein KinasesEnergy MetabolismGene Expression RegulationGene Knockdown TechniquesMechanistic Target of Rapamycin Complex 1MiceModels, BiologicalObesityRas Homolog Enriched in Brain ProteinReceptors, NotchCyclic AMP-Dependent Protein KinasesMechanistic Target of Rapamycin Complex 1Ras Homolog Enriched in Brain ProteinReceptors, NotchUncoupling Protein 1adipose tissuebeigingenergy homeostasisobesitythermogenesis

Identifiers

PMID31220300
PMCPMC6821354
OpenAlexW2953264603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.