ReviewEndocrine reviews2019
Delayed Puberty-Phenotypic Diversity, Molecular Genetic Mechanisms, and Recent Discoveries.
Review in Endocrine reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 49 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 114 citations in OpenAlex.
- Effects of androgen therapy on final adult height in boys with constitutional delay of growth and puberty: a meta-analysis of retrospective cohort studies.BMC endocrine disorders · 2026Pooled it
- Pubertal disorders in juvenile idiopathic arthritis: a systemic review.Journal of pediatric endocrinology & metabolism : JPEM · 2025Pooled it
- Combined HS6ST1 and HS6ST2 loss disrupts the formation and migration of gonadotropin-releasing hormone neurons.Development (Cambridge, England) · 2026Article
- Digital Handholding: The Role of Mobile Decision Support in Early and Delayed Puberty Assessment in Pediatric Practice.Indian journal of pediatrics · 2026Article
- Deoxyinosine enhances GnRH biosynthesis by promoting estradiol production in the hypothalamus and ovaries.Science China. Life sciences · 2026Article
- MECP2 Rare Variants in Boys With Central Precocious Puberty.The Journal of clinical endocrinology and metabolism · 2026Article
- Clinical approach to the male with delayed puberty.Archives of endocrinology and metabolism · 2025Review
- Association between early age at menarche and overactive bladder risk in women: insights from NHANES and Mendelian randomization analysis.Translational andrology and urology · 2025Article
- Determination of Androgen Bioactivity by an In Vitro Assay During Pubertal Transition in Healthy Boys.Clinical endocrinology · 2025Article
- Sex and age differences on how testosterone relates to brain activity during working memory among adolescents and young adults.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- The hippo pathway: a molecular bridge between environmental cues and pace of life.BMC ecology and evolution · 2025Review
- Trends of Age at Onset of Menarche Among Indian Women of Reproductive Age and Its Association with the Presence of PCOS and Related Features: A Multicentric Cross Sectional Study.Journal of obstetrics and gynaecology of India · 2025Article
- Progressive Impairment of Prepubertal Growth in Children With APECED.The Journal of clinical endocrinology and metabolism · 2025Article
- Genetics and Epigenetics of Human Pubertal Timing: The Contribution of Genes Associated With Central Precocious Puberty.Journal of the Endocrine Society · 2025Review
- Availability, Usage, and Preferences of Estradiol and Progestogen Preparations for Puberty Induction from a Multicentral Perspective.Hormone research in paediatrics · 2025Article
- A Current Perspective on Delayed Puberty and Its ManagementJournal of clinical research in pediatric endocrinology · 2024Review
- Disorders of puberty and neurodevelopment: A shared etiology?Annals of the New York Academy of Sciences · 2024Review
- The Spectrum of Hypogonadism in Women From Basrah.Cureus · 2024Article
- Clinical, genetic profile and therapy evaluation of 11 Chinese pediatric patients with Fanconi-Bickel syndrome.Orphanet journal of rare diseases · 2024Article
- Outcomes and experiences of adults with congenital hypogonadism can inform improvements in the management of delayed puberty.Journal of pediatric endocrinology & metabolism : JPEM · 2024Review
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
This review presents a comprehensive discussion of the clinical condition of delayed puberty, a common presentation to the pediatric endocrinologist, which may present both diagnostic and prognostic challenges. Our understanding of the genetic control of pubertal timing has advanced thanks to active investigation in this field over the last two decades, but it remains in large part a fascinating and mysterious conundrum. The phenotype of delayed puberty is associated with adult health risks and common etiologies, and there is evidence for polygenic control of pubertal timing in the general population, sex-specificity, and epigenetic modulation. Moreover, much has been learned from comprehension of monogenic and digenic etiologies of pubertal delay and associated disorders and, in recent years, knowledge of oligogenic inheritance in conditions of GnRH deficiency. Recently there have been several novel discoveries in the field of self-limited delayed puberty, encompassing exciting developments linking this condition to both GnRH neuronal biology and metabolism and body mass. These data together highlight the fascinating heterogeneity of disorders underlying this phenotype and point to areas of future research where impactful developments can be made.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.