ArticleCerebral cortex (New York, N.Y. : 1991)2020
The Role of Primate Prefrontal Cortex in Bias and Shift Between Visual Dimensions.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Thalamocortical regulation of prefrontal stability enables abstract rule generalization.Science advances · 2026Article
- Sex dependency of subconscious visual perception.Biology of sex differences · 2025Article
- Article
- Adaptive Reinforcement Learning is causally supported by Anterior Cingulate Cortex and Striatum.bioRxiv : the preprint server for biology · 2025Article
- How Do Common Marmosets Maintain the Balance Between Response Execution and Action Inhibition?American journal of primatology · 2025Article
- Alcohol, flexible behavior, and the prefrontal cortex: Functional changes underlying impaired cognitive flexibility.Neuropharmacology · 2024Review
- Direct current stimulation modulates prefrontal cell activity and behaviour without inducing seizure-like firing.Brain : a journal of neurology · 2024Article
- Morphine exposure modulates dimensional bias and set formation in anthropoids.Addiction biology · 2024Article
- Mapping causal links between prefrontal cortical regions and intra-individual behavioral variability.Nature communications · 2024Article
- Dose-Dependent Dissociation of Pro-cognitive Effects of Donepezil on Attention and Cognitive Flexibility in Rhesus Monkeys.Biological psychiatry global open science · 2023Article
- How Can Animal Models Inform the Understanding of Cognitive Inflexibility in Patients with Anorexia Nervosa?Journal of clinical medicine · 2022Review
- Dimension of visual information interacts with working memory in monkeys and humans.Scientific reports · 2022Article
- Dissecting the Prefrontal Network With Pathway-Selective Manipulation in the Macaque Brain-A Review.Frontiers in neuroscience · 2022Review
- Dissociable effects of music and white noise on conflict-induced behavioral adjustments.Frontiers in neuroscience · 2022Article
- Dimensional bias and adaptive adjustments in inhibitory control of monkeys.Animal cognition · 2021Article
- Short-term research projects in cognitive neuroscience for undergraduate students: a contingency plan to maintain quality teaching during COVID-19 pandemic.Advances in physiology education · 2021Article
- Simultaneous Damage of the Cingulate Cortex Zone II and Fronto-Striatal Circuit Causes Prolonged Selective Attentional Deficits.Frontiers in human neuroscience · 2021Article
- Emergence of abstract rules in the primate brain.Nature reviews. Neuroscience · 2020Review
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Authors and funding
4 authors.
Funding
Abstract
Imaging and neural activity recording studies have shown activation in the primate prefrontal cortex when shifting attention between visual dimensions is necessary to achieve goals. A fundamental unanswered question is whether representations of these dimensions emerge from top-down attentional processes mediated by prefrontal regions or from bottom-up processes within visual cortical regions. We hypothesized a causative link between prefrontal cortical regions and dimension-based behavior. In large cohorts of humans and macaque monkeys, performing the same attention shifting task, we found that both species successfully shifted between visual dimensions, but both species also showed a significant behavioral advantage/bias to a particular dimension; however, these biases were in opposite directions in humans (bias to color) versus monkeys (bias to shape). Monkeys' bias remained after selective bilateral lesions within the anterior cingulate cortex (ACC), frontopolar cortex, dorsolateral prefrontal cortex (DLPFC), orbitofrontal cortex (OFC), or superior, lateral prefrontal cortex. However, lesions within certain regions (ACC, DLPFC, or OFC) impaired monkeys' ability to shift between these dimensions. We conclude that goal-directed processing of a particular dimension for the executive control of behavior depends on the integrity of prefrontal cortex; however, representation of competing dimensions and bias toward them does not depend on top-down prefrontal-mediated processes.
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