ArticleCerebral cortex (New York, N.Y. : 1991)2020
Multiscale Structure-Function Gradients in the Neonatal Connectome.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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71 citing papers in PubMed.
- Cascading Periods of Language-Related Brain Plasticity Across Early Childhood.Developmental science · 2026Article
- Structure-function coupling of large-scale cortical networks across the lifespan is spectrally specific.Communications biology · 2026Article
- Opportunities and pitfalls of data contextualization in neuroimaging.Nature reviews. Neuroscience · 2026Review
- White matter structure-function coupling in neonatal brain and its association with Autism-related traits in early childhood.Translational psychiatry · 2026Article
- Functional brain growth trajectories across the first decade of life from a single longitudinal cohort.Research square · 2026Article
- Brain functional-structural gradient coupling reflects development, behavior and genetic influences.Nature communications · 2026Article
- Spatiotemporal dynamics of the human cortical functional hierarchy across the lifespan.Nature communications · 2026Article
- Article
- Cascading periods of language-related brain plasticity across early childhood.bioRxiv : the preprint server for biology · 2026Article
- Prenatal and early postnatal periods differentially shape the maturation of human cortical microstructure and myelin.PLoS biology · 2026Article
- The biological role of local and global fMRI BOLD signal variability in multiscale human brain organization.Nature communications · 2026Article
- Functional gradient variations in different neuroticism levels and its correlation with cell type-specific transcriptional signatures.Social cognitive and affective neuroscience · 2026Article
- Developmental variations in recurrent spatiotemporal brain propagations from childhood to adulthood.Nature communications · 2026Article
- Spontaneous Fluctuations in Alpha Peak Frequency along the Posterior-to-Anterior Cortical Plane.eNeuro · 2026Article
- Microstructural profiles of the human superficial white matter and their associations to cortical geometry and connectivity.PLoS biology · 2026Article
- Dynamic structure-function coupling in macroscale neonatal brain networks.Communications biology · 2025Article
- Transcriptomic divergence of network hubs in the prenatal human brain.Communications biology · 2025Article
- Assessment of resting state structural-functional relationships in perisylvian region during the early weeks after birth.Brain structure & function · 2025Article
- Maturation of Neuronal Activity in the Human Cortex Exhibits Robust Spatial Gradients across the Birth Transition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Emergence of a synergistic scaffold in the brains of human infants.Communications biology · 2025Article
11 more citing papers are in PubMed but not listed here.
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8 authors.
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Abstract
The adult functional connectome is well characterized by a macroscale spatial gradient of connectivity traversing from unimodal toward higher-order transmodal cortices that recapitulates known principles of hierarchical organization and myelination patterns. Despite an emerging literature assessing connectome properties in neonates, the presence of connectome gradients and particularly their correspondence to microstructure remains largely unknown. We derived connectome gradients using unsupervised techniques applied to functional connectivity data from 40 term-born neonates. A series of cortex-wide analysis examined associations to magnetic resonance imaging-derived morphological parameters (cortical thickness, sulcal depth, curvature), measures of tissue microstructure (intracortical T1w/T2w intensity, superficial white matter diffusion parameters), and subcortico-cortical functional connectivity. Our findings indicate that the primary neonatal connectome gradient runs between sensorimotor and visual anchors and captures specific associations to cortical and superficial white matter microstructure as well as thalamo-cortical connectivity. A second gradient indicated an anterior-to-posterior asymmetry in macroscale connectivity alongside an immature differentiation between unimodal and transmodal areas, indicating a connectome-level circuitry en route to an adult-like organization. Our findings reveal an important coordination of structural and functional interactions in the neonatal connectome across spatial scales. Observed associations were replicable across individual neonates, suggesting consistency and generalizability.
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