ArticlePloS one2019
Green synthesis of silver nanoparticles via Cynara scolymus leaf extracts: The characterization, anticancer potential with photodynamic therapy in MCF7 cells.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
78 citing papers in PubMed, 287 citations in OpenAlex.
- Green Synthesis and Characterization of Silver Nanoparticles Using Traditional Medicinal Herb Phyllanthus Maderaspatensis for their Antibacterial and Anti-biofilm Activities.Applied biochemistry and biotechnology · 2026Article
- Synergistic Photodynamic Antimicrobial Therapy Using 405 nm Laser Diode and Moringa Oleifera-Derived Silver Nanoparticles against Pathogenic Bacteria.Journal of lasers in medical sciences · 2026Article
- Biochemical Reduction of Metal Salts as a Prominent Approach for Biohybrid Nanomaterials Production: A Review.Nanomaterials (Basel, Switzerland) · 2025Review
- Antimicrobial Profile of MoldovanAntibiotics (Basel, Switzerland) · 2025Article
- A novel approach for phyto-synthesis of silver nanoparticles using floral extract of Punica granatum for potent anti-cancerous and antibacterial capabilities.Discover nano · 2025Article
- Rational engineering of nanoplatforms with hierarchical targeting hepatic tumor and subcellular mitochondria for enhanced image-guided photodynamic therapy.Journal of nanobiotechnology · 2025Article
- Characterization and Performance Evaluation of Cotton Fabrics Functionalized via In Situ Green Synthesis of Silver Nanoparticles UsingPolymers · 2025Article
- Development of collagen-based hydrogel derived from allicin-silver nanoparticles for wound healing.Die Naturwissenschaften · 2025Article
- Article
- Mycosynthesis of silver nanoparticles by Aspergillus templicola OR480102: a multifaceted approach for antibacterial, anticancer, and scratch assay applications.BMC biotechnology · 2025Article
- Investigation of antibacterial and anticancer activities of biosynthesized metal-doped and undoped zinc oxide nanoparticles.Biotechnology and applied biochemistry · 2025Article
- Advancements in Green Synthesis of Silver-Based Nanoparticles: Antimicrobial and Antifungal Properties in Various Films.Nanomaterials (Basel, Switzerland) · 2025Review
- Enhancing the Therapeutic Effect and Bioavailability of Irradiated Silver Nanoparticle-Capped Chitosan-Coated Rosuvastatin Calcium Nanovesicles for the Treatment of Liver Cancer.Pharmaceutics · 2025Article
- New approaches of green silver nanoparticles for cancer and biomedical applications: a review.Exploration of targeted anti-tumor therapy · 2025Review
- Biosynthesis and characterization of silver nanoparticles from Asplenium dalhousiae and their potential biological properties.PloS one · 2025Article
- Global Research Trends and Recent Advances in Medicinal Plant-Synthesized Nanoparticles for Cancer Treatment.Plants (Basel, Switzerland) · 2024Article
- Eco-synthesis of green silver nanoparticles using natural extracts and its application as co-catalyst in photocatalytic hydrogen production.RSC advances · 2024Article
- Impeding microbial biofilm formation and Pseudomonas aeruginosa virulence genes using biologically synthesized silver Carthamus nanoparticles.Microbial cell factories · 2024Article
- Nanoparticle-mediated diagnosis, treatment, and prevention of breast cancer.Nanoscale advances · 2024Review
- Use of Residual Malt from an Artisanal Beer Brewing Process in the Biosynthesis of Silver Nanoparticles Mediated by Nucleating and Structure-Directing Agents.Molecules (Basel, Switzerland) · 2024Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we report on the synthesis of silver nanoparticles (AgNPs) from the leaf extracts of Cynara scolymus (Artichoke) using microwave irradiation and the evaluation of its anti-cancer potential with photodynamic therapy (PDT). Silver nanoparticles formation was characterized by scanning electron microscopy with energy dispersive x-ray spectroscopy and Fourier transform infrared (FTIR) spectroscopy. Silver nanoparticles formation was also investigated the surface charge, particle size and distribution using zetasizer analysis. The cytotoxic effect of AgNPs and/or PDT was studied by MTT assay and migration by the scratch assay. The apoptotic inducing ability of the AgNPs and/or PDT was investigated by intracellular ROS analysis, antioxidant enzyme levels (SOD, CAT, GPx and GSH), Hoechst staining and Bax/Bcl-2 analysis using western blotting. The mean particle size of produced AgNPs was found 98.47±2.04 nm with low polydispersity (0.301±0.033). Zeta potential values of AgNPs show -32.3± 0.8 mV. These results clearly indicate the successful formation of AgNPs for cellular uptake. Mitochondrial damage and intracellular ROS production were observed upon treatment with AgNPs (10μg/mL) and PDT (0.5 mJ/cm2) showed significant reducing cell migration, expression of Bax and suppression of Bcl-2. Significantly, biosynthesized AgNPs showed a broad-spectrum anti-cancer activity with PDT therapy and therefore represent promoting ROS generation by modulating mitochondrial apoptosis induction in MCF7 breast cancer cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.