ArticlePloS one2019
Very severe anemia and one year mortality outcome after hospitalization in Tanzanian children: A prospective cohort study.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- The Gut-Iron-Immune Axis in Severe Anaemia and Bacteraemia.Nutrients · 2026Review
- The Effect of Anemia on Mortality in Children Hospitalized with Severe Pneumonia in Uganda.The Journal of pediatrics · 2026Article
- Association between Iron-Folic Acid Supplementation during Pregnancy and Maternal and Infant Anemia in West Java, Indonesia: A Mixed-Method Prospective Cohort Study.The American journal of tropical medicine and hygiene · 2024Article
- Pediatric post-discharge mortality in resource-poor countries: a systematic review and meta-analysis.EClinicalMedicine · 2024Article
- Mortality after hospital discharge among children younger than 5 years admitted with suspected sepsis in Uganda: a prospective, multisite, observational cohort study.The Lancet. Child & adolescent health · 2023Observational
- Child anemia in Cambodia: A descriptive analysis of temporal and geospatial trends and logistic regression-based examination of factors associated with anemia in children.PLOS global public health · 2023Article
- Hemoglobin life-threatening value (1.9 g/dl) in good general condition: a pediatric case-report.Italian journal of pediatrics · 2021Article
- Challenges in pediatric post-sepsis care in resource limited settings: a narrative review.Translational pediatrics · 2021Review
- AnemoCheck-LRS: an optimized, color-based point-of-care test to identify severe anemia in limited-resource settings.BMC medicine · 2020Article
- Mortality during and following hospital admission among school-aged children: a cohort study.Wellcome open research · 2020Article
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Authors and funding
10 authors at 5 institutions in 4 countries.
Funding
Abstract
backgroundAfrica has the highest rates of child mortality. Little is known about outcomes after hospitalization for children with very severe anemia.
objectiveTo determine one year mortality and predictors of mortality in Tanzanian children hospitalized with very severe anemia.
methodsWe conducted a prospective cohort study enrolling children 2-12 years hospitalized from August 2014 to November 2014 at two public hospitals in northwestern Tanzania. Children were screened for anemia and followed until 12 months after discharge. The primary outcome measured was mortality. Predictors of mortality were determined using Cox regression analysis.
resultsOf the 505 children, 90 (17.8%) had very severe anemia and 415 (82.1%) did not. Mortality was higher for children with very severe anemia compared to children without over a one year period from admission, 27/90 (30.0%) vs. 59/415 (14.2%) respectively (Hazard Ratio (HR) 2.42, 95% Cl 1.53-3.83). In-hospital mortality was 11/90 (12.2%) and post-hospital mortality was 16/79 (20.2%) for children with very severe anemia. The strongest predictors of mortality were age (HR 1.01, 95% Cl 1.00-1.03) and decreased urine output (HR 4.30, 95% Cl 1.04-17.7).
conclusionsChildren up to 12 years of age with very severe anemia have nearly a 30% chance of mortality following admission over a one year period, with over 50% of mortality occurring after discharge. Post-hospital interventions are urgently needed to reduce mortality in children with very severe anemia, and should include older children.
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