ArticleJournal of pediatric gastroenterology and nutrition2019
The Risk of Autoimmune Disorders in Treated Celiac Disease Patients in Olmsted County, Minnesota.
Article in Journal of pediatric gastroenterology and nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Autoantibody signatures in children with celiac disease, juvenile idiopathic arthritis, and polyautoimmunity.JPGN reports · 2026Article
- Parameters associated with the development of autoimmune diseases in pediatric onset celiac disease.European journal of pediatrics · 2025Article
- Celiac Disease in Children: A 2023 Update.Indian journal of pediatrics · 2024Review
- A Mouse Model of Celiac Disease.Current protocols · 2022Article
- Association of concomitant autoimmunity with the disease features and long-term treatment and health outcomes in Celiac disease.Frontiers in medicine · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPatients with autoimmune disorders (ADs) are at increased risk for celiac disease (CD), but data are conflicting on the risk of ADs in treated patients with CD. We aimed to assess the incidence of ADs in treated patients with CD.
methodsUsing the Rochester Epidemiology Project, we retrospectively searched for the medical records at Mayo Clinic and Olmsted Medical Center from January 1997 to December 2015 for patients with CD who met accepted diagnostic criteria. For each patient with CD, we identified 2 age and sex-matched controls during the same study period. The incidence rate of AD diagnosis 5 years after index date was calculated using Kaplan-Meier analysis for the CD cases and controls and compared using the log-rank test.
resultsWe identified 249 treated patients with CD during the study period and 498 matched controls, with mean (standard deviation) ages of 32 (22) years and 33 (22) years, respectively. One third of patients (n = 85) and controls (n = 170) were boys. Five years after the index date, 5.0% of patients with CD and 1.3% of controls had a de novo AD diagnosis (P = 0.006). In the presence of a prior AD, the cumulative risk of a de novo or additional AD was significantly higher in the CD group compared with controls (P < 0.001). Children had a significantly higher risk of AD development compared with adults (P = 0.010).
conclusionsTreated patients with CD are at higher risk for the development of ADs. The risk of a new AD is higher in children, especially when >1 AD diagnosis exists.
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