Evidence map›Paper›PMID 31219800›Full record

ArticleAging2019

Long-time qingyan formula extract treatment exerts estrogenic activities on reproductive tissues without side effects in ovariectomized rats and via active ER to ERE-independent gene regulation.

Hong-Xia Zheng, Yuan Zhao, Ying Xu, Zi-Jia Zhang, Jing-Jing Zhu, Yuan-Fang Fan, Na Lin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Complex Extract ofNutrients · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Hong-Xia ZhengInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Yuan ZhaoInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Ying XuInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Zi-Jia ZhangInstitute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Jing-Jing ZhuInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Yuan-Fang FanInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Na LinInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNShanghai University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The reproductive tissues are negatively influenced by estrogens in hormone therapy. Qingyan formula ethanol extract (QYFE)'s estrogenic effects and safety on reproductive tissues after long-term administration and its mechanism via estrogen receptor (ER) pathway haven't been studied. Here, we characterized its estrogenic effects using ovariectomized rats together with

Indexed as

Adrenal GlandsAnimalsBreast NeoplasmsCell Line, TumorDrugs, Chinese HerbalEstradiolEstrogen Receptor alphaEstrogen Receptor betaFemaleGene Expression RegulationHumansKi-67 AntigenMammary Glands, HumanOvariectomyProliferating Cell Nuclear AntigenRatsDrugs, Chinese HerbalEstradiolEstrogen Receptor alphaEstrogen Receptor betaKi-67 AntigenProliferating Cell Nuclear Antigenqingyanestrogenic effectestrogen receptor antagonist ICI182,780estrogen receptorsreproductive target tissue

Identifiers

PMID31219800
PMCPMC6628985
OpenAlexW2954373669

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.