ArticlemSystems2019
Clonal yet Different: Understanding the Causes of Genomic Heterogeneity in Microbial Species and Impacts on Public Health.
Article in mSystems, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Exploring clonality ofMicrobiology spectrum · 2026Article
- Comparing Prescribing Behaviors and Clinician Experiences Between Multiplex PCR/Pooled Antibiotic Susceptibility Testing and Standard Urine Culture in Complicated UTI Cases.Journal of clinical medicine · 2024Article
- Hound: a novel tool for automated mapping of genotype to phenotype in bacterial genomes assembled de novo.Briefings in bioinformatics · 2024Article
- Dynamic state of plasmid genomic architectures resulting from XerC/D-mediated site-specific recombination inFrontiers in microbiology · 2023Article
- Single-Cell Microgels for Diagnostics and Therapeutics.Advanced functional materials · 2021Article
- Within-host microevolution of Streptococcus pneumoniae is rapid and adaptive during natural colonisation.Nature communications · 2020Article
- Microbiome-Aware Ecotoxicology of Organisms: Relevance, Pitfalls, and Challenges.Frontiers in public health · 2020Review
- Pan-genome diversification and recombination in Cronobacter sakazakii, an opportunistic pathogen in neonates, and insights to its xerotolerant lifestyle.BMC microbiology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Why are members of a microbial species not the same? They may be clonal, but microbial populations are often composed of multiple cocirculating lineages distinguished by large phenotypic and genetic differences. Species and the mechanisms of speciation have been notoriously challenging to study in microbes owing to pervasive horizontal gene flow, widespread geographical distribution, and cryptic ecological niches that structure microbial populations. Understanding the origins of genomic variation in microbial species and populations is fundamental to questions critical to society and public health, such as "Are emerging diseases new species or variants of existing ones?," "What makes a resistant strain successful?," and "How will a pathogen respond to selective pressures?" To explore these questions, I use whole-genome sequencing of closely related strains to understand the evolutionary, ecological, and epidemiological dynamics of bacterial pathogens to inform effective, more precisely targeted public health interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.