Evidence map›Paper›PMID 31219754›Full record

ArticlemAbs

Preclinical and translational pharmacokinetics of a novel THIOMAB™ antibody-antibiotic conjugate against

Rong Deng, Chenguang Zhou, Dongwei Li, Hao Cai, Siddharth Sukumaran, Montserrat Carrasco-Triguero, Ola Saad, Denise Nazzal, Christopher Lowe, Saroja Ramanujan and 1 more

Open access · goldAbstract read
In one paragraph

Article in mAbs. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 39 citations in OpenAlex.

  1. Monoclonal Antibodies Targeting Bacterial Infections: A Broad Review of the Field.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Introduction of Carbonyl Groups into Antibodies.Molecules (Basel, Switzerland) · 2023
    Review
  10. Review
  11. Review
  12. Vancomycin Resistance inMicroorganisms · 2022
    Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rong Denga Research and Early Development, Genentech Inc ., South San Francisco , CA , USA.
Chenguang Zhoua Research and Early Development, Genentech Inc ., South San Francisco , CA , USA.
Dongwei Lia Research and Early Development, Genentech Inc ., South San Francisco , CA , USA.
Hao Caia Research and Early Development, Genentech Inc ., South San Francisco , CA , USA.ORCID 0000-0002-4937-085X
Siddharth Sukumarana Research and Early Development, Genentech Inc ., South San Francisco , CA , USA.
Montserrat Carrasco-Trigueroa Research and Early Development, Genentech Inc ., South San Francisco , CA , USA.
Ola Saada Research and Early Development, Genentech Inc ., South San Francisco , CA , USA.ORCID 0000-0002-2607-8901
Denise Nazzala Research and Early Development, Genentech Inc ., South San Francisco , CA , USA.
Christopher Lowea Research and Early Development, Genentech Inc ., South San Francisco , CA , USA.
Saroja Ramanujana Research and Early Development, Genentech Inc ., South San Francisco , CA , USA.
Amrita V Kamatha Research and Early Development, Genentech Inc ., South San Francisco , CA , USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DSTA4637S, a novel THIOMAB™ antibody-antibiotic conjugate (TAC) against

Indexed as

Antibodies, BacterialAntibodies, MonoclonalImmunoconjugatesImmunoglobulin GRifamycinsAnimalsMacaca fascicularisMaleRatsRats, Sprague-DawleyStaphylococcus aureusAntibodies, BacterialAntibodies, MonoclonalImmunoconjugatesImmunoglobulin GRifamycinsallometric scalingPharmacokineticssemi-mechanistic pharmacokinetic modelStaphylococcus aureusTHIOMAB™ antibody-antibiotic conjugate (TAC)translation

Identifiers

PMID31219754
PMCPMC6748576
OpenAlexW2953299247

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.