Evidence map›Paper›PMID 31219738›Full record

ReviewCirculation research2019

Emerging Concepts in Precision Medicine and Cardiovascular Diseases in Racial and Ethnic Minority Populations.

George A Mensah, Cashell Jaquish, Pothur Srinivas, George J Papanicolaou, Gina S Wei, Nicole Redmond, Megan C Roberts, Cheryl Nelson, Larissa Aviles-Santa, Mona Puggal and 7 more

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Circulation research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
7.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. How Sex and Race/Ethnicity Influence Interventional Cardiology Outcomes: What Do We Know?Journal of the Society for Cardiovascular Angiography & Interventions · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Hypermethylation ofJournal of the American Heart Association · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Barriers and Facilitators to Genetic Education, Risk Assessment, and Testing: Considerations on Advancing Equitable Genetics Care.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2023
    Article
  16. Article
  17. Observational
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

George A MensahFrom the Center for Translation Research and Implementation Science (G.A.M., M.C.G.P., W.B., K.N.F., C.A.B., M.M.E.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Cashell JaquishDivision of Cardiovascular Sciences (C.J., P.S., G.J.P., G.S.W., N.R., C.N., L.A.-S., M.P., M.A.M.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Pothur SrinivasDivision of Cardiovascular Sciences (C.J., P.S., G.J.P., G.S.W., N.R., C.N., L.A.-S., M.P., M.A.M.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
George J PapanicolaouDivision of Cardiovascular Sciences (C.J., P.S., G.J.P., G.S.W., N.R., C.N., L.A.-S., M.P., M.A.M.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Gina S WeiDivision of Cardiovascular Sciences (C.J., P.S., G.J.P., G.S.W., N.R., C.N., L.A.-S., M.P., M.A.M.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Nicole RedmondDivision of Cardiovascular Sciences (C.J., P.S., G.J.P., G.S.W., N.R., C.N., L.A.-S., M.P., M.A.M.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Megan C RobertsUniversity of North Carolina, Chapel Hill (M.C.R.).
Cheryl NelsonDivision of Cardiovascular Sciences (C.J., P.S., G.J.P., G.S.W., N.R., C.N., L.A.-S., M.P., M.A.M.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Larissa Aviles-SantaDivision of Cardiovascular Sciences (C.J., P.S., G.J.P., G.S.W., N.R., C.N., L.A.-S., M.P., M.A.M.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Mona PuggalDivision of Cardiovascular Sciences (C.J., P.S., G.J.P., G.S.W., N.R., C.N., L.A.-S., M.P., M.A.M.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Melissa C Green ParkerFrom the Center for Translation Research and Implementation Science (G.A.M., M.C.G.P., W.B., K.N.F., C.A.B., M.M.E.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Mollie A MinearDivision of Cardiovascular Sciences (C.J., P.S., G.J.P., G.S.W., N.R., C.N., L.A.-S., M.P., M.A.M.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Whitney BarfieldFrom the Center for Translation Research and Implementation Science (G.A.M., M.C.G.P., W.B., K.N.F., C.A.B., M.M.E.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Kathleen N FentonFrom the Center for Translation Research and Implementation Science (G.A.M., M.C.G.P., W.B., K.N.F., C.A.B., M.M.E.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Cheryl Anne BoyceFrom the Center for Translation Research and Implementation Science (G.A.M., M.C.G.P., W.B., K.N.F., C.A.B., M.M.E.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Michael M EngelgauFrom the Center for Translation Research and Implementation Science (G.A.M., M.C.G.P., W.B., K.N.F., C.A.B., M.M.E.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Muin J KhouryOffice of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA (M.J.K.).
National Institutes of Health · USNational Heart Lung and Blood Institute · USCenters for Disease Control and Prevention · USUniversity of North Carolina at Chapel Hill · US

Funding

Intramural NIH HHS Z99 HL999999
6 · The paper itself

Abstract

Cardiovascular diseases remain the leading cause of mortality and a major contributor to preventable deaths worldwide. The dominant modifiable risk factors and the social and environmental determinants that increase cardiovascular risk are known, and collectively, are as important in racial and ethnic minority populations as they are in majority populations. Their prevention and treatment remain the foundation for cardiovascular health promotion and disease prevention. Genetic and epigenetic factors are increasingly recognized as important contributors to cardiovascular risk and provide an opportunity for advancing precision cardiovascular medicine. In this review, we explore emerging concepts at the interface of precision medicine and cardiovascular disease in racial and ethnic minority populations. Important among these are the lack of racial and ethnic diversity in genomics studies and biorepositories; the resulting misclassification of benign variants as pathogenic in minorities; and the importance of ensuring ancestry-matched controls in variant interpretation. We address the relevance of epigenetics, pharmacogenomics, genetic testing and counseling, and their social and cultural implications. We also examine the potential impact of precision medicine on racial and ethnic disparities. The National Institutes of Health's All of Us Research Program and the National Heart, Lung, and Blood Institute's Trans-Omics for Precision Medicine Initiative are presented as examples of research programs at the forefront of precision medicine and diversity to explore research implications in minorities. We conclude with an overview of implementation research challenges in precision medicine and the ethical implications in minority populations. Successful implementation of precision medicine in cardiovascular disease in minority populations will benefit from strategies that directly address diversity and inclusion in genomics research and go beyond race and ethnicity to explore ancestry-matched controls, as well as geographic, cultural, social, and environmental determinants of health.

Indexed as

EthnicityMinority GroupsCardiovascular DiseasesHealthcare DisparitiesHealth Services AccessibilityHumansPrecision Medicineancestrybioethicsgeneticsgenomicspharmacogeneticsprecision medicine

Identifiers

PMID31219738
PMCPMC6590684
OpenAlexW2952785442

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.