Evidence map›Paper›PMID 31219624›Full record

ArticleAmerican journal of industrial medicine2019

Administration of antineoplastic drugs and fecundity in female nurses.

Feiby L Nassan, Christina C Lawson, Audrey J Gaskins, Candice Y Johnson, James M Boiano, Janet W Rich-Edwards, Jorge E Chavarro

Open access · greenAbstract read
In one paragraph

Article in American journal of industrial medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Safe handling of hazardous drugs.Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners · 2023
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Feiby L NassanDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.ORCID 0000-0002-3204-0694
Christina C LawsonCenters for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio.ORCID 0000-0002-3401-3921
Audrey J GaskinsDepartment of Nutrition, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.ORCID 0000-0003-0812-7439
Candice Y JohnsonCenters for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio.ORCID 0000-0002-2544-3110
James M BoianoCenters for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio.ORCID 0000-0003-2738-4588
Janet W Rich-EdwardsDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.ORCID 0000-0001-5066-8808
Jorge E ChavarroDepartment of Nutrition, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Brigham and Women's Hospital · USCenters for Disease Control and Prevention · USMassachusetts Department of Public Health · US

Funding

Maternal Exposure to Air Pollution and Early Pregnancy OutcomesR00ES026648 · NIEHS · EMORY UNIVERSITY · PI GASKINS, AUDREY JANE · 2019 to 2021
$730k
Maternal Exposure to Air Pollution and Early Pregnancy OutcomesK99ES026648 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI GASKINS, AUDREY JANE · 2017 to 2018
$246k
National Institute for Occupational Safety and Health, Contract Number 200-2013-M-54978NIEHS NIH HHS K99 ES026648NIEHS NIH HHS R00 ES026648
6 · The paper itself

Abstract

backgroundWe examined the association between the administration of antineoplastic drugs (AD) and fecundity among female nurses.

methodsAD administration and use of exposure controls (EC) such as gloves, gowns, and needleless systems were self-reported at baseline among 2649 participants of the Nurses' Health Study 3, who were actively attempting pregnancy. Every 6 months thereafter, the nurses reported the current duration of their pregnancy attempt. Multivariable accelerated failure time models were used to estimate time ratios (TR) and 95% confidence intervals (CI) adjusted for age, race, body mass index, smoking, marital status, hours of work, and other occupational risk factors.

resultsMean (standard deviation) age and BMI at baseline were 30.7 years (4.7) and 26.0 kg/m

conclusionsAdministration of ADs did not appear to have an impact on fecundity in a cohort of nurses planning for pregnancy with a high prevalence of consistent ECs. Our results may not be generalizable to women who are less compliant with PPE use or with less availability to ECs. Therefore, it is possible that we did not observe an association between occupational exposure to AD and reduced fecundity because of lower exposure due to the more prevalent use of effective ECs.

Indexed as

AdultAntineoplastic AgentsBody Mass IndexFemaleFertilityHumansInfertility, FemaleNursesOccupational DiseasesOccupational ExposureAntineoplastic Agentsantineoplastic drugsnursesNurses’ Health Studyoccupational exposurepregnancyprotective equipmentreproductive healthtime to pregnancy

Identifiers

PMID31219624
PMCPMC6620132
OpenAlexW2949682694

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.