ArticleSchizophrenia bulletin2020
Electrocardiogram Characteristics and Their Association With Psychotropic Drugs Among Patients With Schizophrenia.
Article in Schizophrenia bulletin, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Exploring the Association Between Mental Disorders and Various Arrhythmias via Mendelian Randomization Methods.Genes, brain, and behavior · 2026Article
- ROS-induced degradation of hERG potassium channels contributes to aripiprazole-induced prolongation of the QTc interval.Acta pharmacologica Sinica · 2026Article
- Prognostic prediction in schizophrenia using the Anderson-Gill time-dependent Cox model: a cohort study in a less-developed region of Southwest China.BMC psychiatry · 2025Article
- Prevalence of cardiovascular risk factors and disease in patients with schizophrenia: baseline results from a prospective cohort study with long-term clinical follow-up.Schizophrenia (Heidelberg, Germany) · 2025Article
- QT interval prolongation in schizophrenia: A cross-sectional study from a tertiary care center in Raipur.The Indian journal of medical research · 2025Article
- Comparative risk of QTc prolongation induced by second-generation antipsychotics in the real world: retrospective cohort study based on a hospital information system.BJPsych open · 2025Article
- Severe mental illness: cardiovascular risk assessment and management.European heart journal · 2024Article
- Abnormal blood lipid and electrocardiogram characteristics in common mental disorders.BMC psychiatry · 2023Article
- Cardiovascular autonomic reflex tests using a handheld device in the diagnosis of cardiovascular autonomic neuropathy in patients with schizophrenia.American heart journal plus : cardiology research and practice · 2023Article
- Coronary Artery Disease in Patients with Severe Mental Illness.Interventional cardiology (London, England) · 2023Review
- The Effect of Antipsychotics and Their Combinations with Other Psychotropic Drugs on Electrocardiogram Intervals Other Than QTc among Jordanian Adult Outpatients.Biomedicines · 2022Article
- High dose antipsychotic polypharmacy and dopamine partial agonists - time to rethink guidelines?Journal of psychopharmacology (Oxford, England) · 2021Article
- Association Between ECG Abnormalities and Fatal Cardiovascular Disease Among Patients With and Without Severe Mental Illness.Journal of the American Heart Association · 2021Article
- The Prevalence, Risk Factors and Clinical Correlates of QTc Prolongation in Chinese Hospitalized Patients With Chronic Schizophrenia.Frontiers in psychiatry · 2021Article
- Higher risk of major adverse cardiac events after acute myocardial infarction in patients with schizophrenia.Open heart · 2020Observational
- Impairment of the cardiac ejection fraction by blocking dopamine D2 receptors induced by long-acting injectable antipsychotic treatment.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
- Validation of a Clinical Decision Support Tool for Quantifying Risk of Torsades de Pointes in a Psychiatric Inpatient Population.Innovations in clinical neuroscienceArticle
- QT interval prolongation from antipsychotics in schizophrenia and acute psychosis - A prospective study.Industrial psychiatry journalArticle
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13 authors.
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Abstract
backgroundThere are limited data on electrocardiogram (ECG) characteristics and their association with psychotropic drugs in schizophrenia.
methodsUsing a cross-sectional design, we included Danish primary care patients with first-time digital ECGs from 2001 to 2015. Patients diagnosed with schizophrenia before ECG recording were matched 1:5 on age, sex, and ECG recording year to controls without psychiatric disease. Multivariable logistic regression was used to compute odds ratios (ORs) with 95% confidence intervals (CIs).
resultsWe included 4486 patients with schizophrenia matched with 22 430 controls (median age, 47 years; male, 55%). Between groups, the prevalence of abnormal ECGs was similar (54%, P = .536), but patients with schizophrenia demonstrated higher median heart rate (79 vs 69 beats per minute, P < .001) and Fridericia-corrected QT (QTc) interval (416 vs 412 ms, P < .001) than controls. QTc prolongation was also more prevalent among patients with schizophrenia (3.4% vs 1.1%, P < .001), and so were pathological Q waves (5.3% vs 3.9%, P < .001). Patients with schizophrenia less frequently demonstrated left ventricular hypertrophy (6.1% vs 9.6%, P < .001) and atrial fibrillation or flutter (0.7% vs 1.4%, P < .001). Among patients with schizophrenia only, particularly antipsychotics were associated with abnormal ECGs (OR, 1.20; 95% CI, 1.04-1.39).
conclusionsPatients with schizophrenia demonstrate a different cardiovascular risk profile than matched controls without psychiatric disease, with higher prevalence of elevated heart rate, QTc prolongation, and pathological Q waves, and lower prevalence of left ventricular hypertrophy and atrial fibrillation or flutter. Particularly antipsychotics were associated with abnormal ECGs. This underscores an integrated care approach when ECG abnormalities are detected in this group.
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