ArticleNeuropsychology2020
Greater intraindividual variability in neuropsychological performance predicts cognitive impairment in de novo Parkinson's disease.
Article in Neuropsychology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Utilizing Intraindividual Cognitive Variability to Predict Early Neuronal Synuclein Disease Progression.medRxiv : the preprint server for health sciences · 2026Article
- Intraindividual variability, subjective cognitive difficulties, and head injury history in former collegiate athletes.The Clinical neuropsychologist · 2025Article
- Characterizing intraindividual variability in bipolar disorder: links to cognition, white matter microstructure, and clinical variables.Psychological medicine · 2025Article
- Cognitive dispersion and its functional relevance in behavioral variant frontotemporal dementia and prodromal behavioral variant frontotemporal dementia.Neuropsychology · 2024Article
- Recent Advances in Neuropsychological Test Interpretation for Clinical Practice.Neuropsychology review · 2024Review
- Detecting Subtle Cognitive Impairment in Patients with Parkinson's Disease and Normal Cognition: A Novel Cognitive Control Challenge Task (C3T).Brain sciences · 2023Article
- Moving intra-individual variability (IIV) towards clinical utility: IIV measured using a commercial testing platform.Journal of the neurological sciences · 2023Article
- Looking deeper: does a connection exist between fatigue and attentional deficits in Parkinson's disease? A conceptual framework.Frontiers in neurology · 2023Article
- Dispersion-based cognitive intra-individual variability in dementia with Lewy bodies.Neuropsychology · 2022Article
- Intraindividual variability in neuropsychological performance predicts longitudinal cortical volume loss in early Parkinson's disease.Neuropsychology · 2022Article
- Physical inactivity links depressive symptoms and cognitive functioning among individuals with Parkinson's disease.Neuropsychology · 2022Article
- Gastrointestinal symptoms are predictive of trajectories of cognitive functioning in de novo Parkinson's disease.Parkinsonism & related disorders · 2020Article
- Increased intraindividual variability (IIV) in reaction time is the earliest indicator of cognitive change in MS: A two-year observational study.International journal of clinical and health psychology : IJCHPArticle
- Intra-individual variability in cognitive performance predicts functional decline in Parkinson's disease.Applied neuropsychology. AdultArticle
- Linking cognitive variability and Alzheimer's disease biomarkers by neurocognitive status.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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4 authors.
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Abstract
introductionParkinson's disease (PD) is a neurodegenerative disorder that commonly results in cognitive impairments and dementia. Intraindividual variability of neuropsychological performance is a sensitive marker of cognitive decline in other neurologic populations. However, studies have not examined the longitudinal utility of intraindividual variability in predicting future cognitive impairments among individuals with PD. In the current study, we hypothesized that increased intraindividual variability would predict future cognitive decline independent of traditional neuropsychological markers of cognitive impairment.
methodsThe sample included 423 newly diagnosed PD patients and 175 healthy controls, who were followed up to 5 years (baseline, first, second, third, fourth, and fifth annual follow-up). Participants underwent tests of learning, memory, processing speed, attention, verbal fluency, and visuospatial functioning. Cognitive status (cognitive intact, mild cognitive impairment, and dementia) was classified based on previously established criteria. Multilevel models were computed to examine the longitudinal relationship between intraindividual variability, cognitive status, and general cognitive functioning.
resultsAnalyses revealed that increased intraindividual variability was predictive of incident cognitive decline among individuals with PD. Specifically, greater dispersion in neuropsychological performance was associated with greater risk of transitioning from cognitively intact to mild cognitive impairment or transitioning from mild cognitive impairment to dementia. Additional analyses revealed a significant Intraindividual Variability × Group (PD or control) interaction, meaning that intraindividual variability was predictive of declines in cognitive functioning among PD participants only but not healthy controls.
conclusionIntraindividual variability may be a harbinger for future cognitive decline among individuals with PD. (PsycINFO Database Record (c) 2020 APA, all rights reserved).
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