Evidence map›Paper›PMID 31219249›Full record

ArticleMolecular genetics & genomic medicine2019

STAT3 signaling pathway plays importantly genetic and functional roles in HCV infection.

Yuzhu Song, Xianyao Yang, Yunsong Shen, Yiqian Wang, Xueshan Xia, A-Mei Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics & genomic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Polymorphisms of theFrontiers in cellular and infection microbiology · 2023
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yuzhu SongFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China.
Xianyao YangFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China.
Yunsong ShenMolecular Medicine Center of Yunnan Province, Kunming, China.
Yiqian WangFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China.
Xueshan XiaFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China.
A-Mei ZhangFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China.ORCID 0000-0002-6681-3376
Kunming University of Science and Technology · CNSecond People's Hospital of Yunnan Province · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatitis C virus (HCV) infection is an extensive health problem, which leads to serious liver diseases. Host genetic polymorphisms were associated with HCV infection, progression, and treatment effect of patients. Signal transducers and activators of transcription 3 (STAT3) signaling pathway was important to HCV infection, but no genetic association was studied between STAT3 signaling pathway and HCV infection.

methodsTo investigate the genetic and functional roles of the STAT3 signaling pathway, we collected 394 HCV patients and 395 normal controls to genotype 25 signal nucleotide polymorphisms (SNPs) of six genes (Interleukin 6 [IL6, OMIM 147620], Interleukin 6 receptor [IL6R, OMIM 147880], Hepatocyte nuclear factor 1 alpha [HNF1A, OMIM 142410], Hepatocyte nuclear factor 4 alpha [HNF4A, OMIM 600281], STAT3 [OMIM 102582], and ATP binding cassette subfamily C member 2 [ABCC2, OMIM 601107]). Then expression level of these genes were analyzed in HCV infected cells with or without IL6 transfection.

resultsOur results identified that the SNPs in STAT3 signaling pathway were associated with HCV infection or biochemical features of Yunnan HCV patients. Genotype AA of rs4075015 (IL6R) and GG of rs3212172 (HNF4A) increased the risk of HCV infection (p = 0.024 and 0.029), but the genotype AA of rs7553796 (IL6R) played a protective role in HCV infection (p = 0.0008). High-density lipoprotein cholesterol (HDL-C) and Glutamyl transpeptidase (GGT) level were associated with genotypes of rs4845617 (IL6R, p = 0.045) and rs1053023 (STAT3, p = 0.034), respectively. Cell assays suggested that IL6 transfection could suppress HCV proliferation. RNA and protein levels of the IL6R, HNF1A, STAT3, and ABCC2 genes significantly increased after HCV infection.

conclusionWe identified STAT3 signaling pathway influenced HCV infection and biochemical characteristics of HCV patients through genetic and functional aspects.

Indexed as

ATP-Binding Cassette, Sub-Family C ProteinsCell Line, TumorChinaFemaleHepacivirusHepatitis C, ChronicHepatocyte Nuclear Factor 4HepatocytesHumansLiverMaleMultidrug Resistance-Associated Protein 2Polymorphism, Single NucleotideReceptors, Interleukin-6RNA, ViralSignal TransductionABCC2 protein, humanATP-Binding Cassette, Sub-Family C ProteinsHepatocyte Nuclear Factor 4HNF4A protein, humanIL6R protein, humanMultidrug Resistance-Associated Protein 2Receptors, Interleukin-6RNA, ViralSTAT3 protein, humanSTAT3 Transcription Factorbiochemical characteristicsfunctionalgeneticHCVSTAT3 signaling pathway

Identifiers

PMID31219249
PMCPMC6687657
OpenAlexW2949875665

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.