Evidence map›Paper›PMID 31219034›Full record

ArticleeLife2019

piRNA-guided co-transcriptional silencing coopts nuclear export factors.

Martin H Fabry, Filippo Ciabrelli, Marzia Munafò, Evelyn L Eastwood, Emma Kneuss, Ilaria Falciatori, Federica A Falconio, Gregory J Hannon, Benjamin Czech

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
16.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.

  1. Pooled it
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  6. piRNA direct the chromatin reader to its genomic targets.bioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Martin H Fabry *Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-8484-4715
Filippo Ciabrelli *Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0001-7064-4723
Marzia Munafò *Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-2689-8432
Evelyn L EastwoodCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.
Emma KneussCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0003-0662-8539
Ilaria FalciatoriCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.
Federica A FalconioCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.
Gregory J HannonCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0003-4021-3898
Benjamin CzechCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0001-8471-0007
University of Cambridge · GB

Funding

Roles of small RNAs in guarding germ cell genomesR37GM062534 · NIGMS · NEW YORK GENOME CENTER · PI HANNON, GREGORY J · 2013 to 2017
$2.0M
Cancer Research UK 21143NIGMS NIH HHS R37 GM062534
6 · The paper itself

Abstract

The PIWI-interacting RNA (piRNA) pathway is a small RNA-based immune system that controls the expression of transposons and maintains genome integrity in animal gonads. In

Indexed as

Gene SilencingTranscription, GeneticActive Transport, Cell NucleusAnimalsChromatinDrosophila melanogasterNuclear ProteinsProtein BindingProtein StabilityRNA, Small InterferingChromatinNuclear ProteinsRNA, Small InterferingchromosomesD. melanogastergene expressionnuclear export factorpiRNA pathwayPIWI proteinstranscriptional gene silencingtransposon control

Identifiers

PMID31219034
PMCPMC6677536
OpenAlexW2953249056

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.