ReviewDeutsches Arzteblatt international2019
The Use of Activated Charcoal to Treat Intoxications.
Review in Deutsches Arzteblatt international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Therapeutic role of erythropoietin in methanol induced optic neuropathy: a systematic review.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024Pooled it
- Effect of Taste Additives on the Palatability of Activated Charcoal: a Systematic Review.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2023Pooled it
- Effect of Activated Charcoal on Mavacamten Pharmacokinetics in Healthy Participants.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2024Trial
- Pharmacological assessment of drugs retained in the 1Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Activated charcoal in the stomach: Clinical familiarity and limited gross recognition.Forensic science, medicine, and pathology · 2026Article
- Resolving Bivalirudin Interference on Fibrinogen Testing by the Use of Activated Carbon.Journal of clinical laboratory analysis · 2026Article
- Characterizing Apixaban Pharmacokinetics Through Physiologically-Based Pharmacokinetic Modeling: Critical Role of Biliary Secretion and Enterohepatic Circulation in Humans.CPT: pharmacometrics & systems pharmacology · 2026Article
- [Severe intoxication after yew (Taxus) ingestion-case report and literature review].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025Review
- Sonochemically enhanced activated charcoal with improved oral palatability for efficient in vitro detoxification of acetaminophen.Scientific reports · 2025Article
- Greener Solutions in Aflatoxin Management: Transitioning from Conventional Binders to Green Nanotechnology.Nanomaterials (Basel, Switzerland) · 2025Review
- Case report : pyridaben poisoning induced acute respiratory and circulating failure.International journal of emergency medicine · 2025Article
- Alphachloralose intoxication: A retrospective study on epidemiology, clinical presentation, and management in an adult emergency department in Morocco.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2025Article
- Functional Carbon-Based Materials for Blood Purification: Recent Advances Toward Improved Treatment of Renal Failure and Patient Quality of Life.Bioengineering (Basel, Switzerland) · 2025Review
- [Severe and fatal cases of poisoning in the emergency medical services-A 5-year analysis from the Poisoning Information Center North].Die Anaesthesiologie · 2025Article
- A Two-year Retrospective Observational Cohort Study of Benzodiazepine Overdose Cases in the Emergency Department.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- Predictive modeling of methadone poisoning outcomes in children ≤ 5 years: utilizing machine learning and the National Poison Data System for improved clinical decision-making.European journal of pediatrics · 2025Article
- Surface properties and susceptibility to staining of a resin composite after brushing with different whitening toothpastes.Restorative dentistry & endodontics · 2025Article
- Successful Organ Donation After Yew Intoxication.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Case report: Pesticide-related methemoglobinemia: Tebufenozide and indoxacarb poisoning.Frontiers in toxicology · 2025Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn 2016, according to the German Federal Statistical Office, 178 425 cases of intoxication (poisoning) were treated in German hospitals. The poison control centers in the German-speaking countries gave advice in a total of 268 787 instances of poisoning in that year, and use of activated charcoal was recommended in 4.37% of cases. The application of activated charcoal plays a major role in both primary and secondary detoxification. This article serves as an overview of the mechanism of action, indications, contraindications, modes of application, and dosing of activated charcoal.
methodsThis review is based on pertinent publications retrieved by a selective search in PubMed. The opinions of experts from the poison control centers in the German-speaking countries were considered in the interpretation of the data.
resultsThe administration of activated charcoal is indicated to treat moderately severe to life-threatening intoxication. It should be carried out as soon as possible, within the first hour of the ingestion; timed-release preparations can be given up to 6 hours after the ingestion. An important contraindication is impaired consciousness with the danger of aspiration in a patient whose air- way has not yet been secured. Activated charcoal is ineffective or inadequately effective in cases of poisoning with acids or bases, alcohols, organic solvents, inorganic salts, or metals. The proper dosage consists of an amount that is 10 to 40 times as much as that of the intoxicating substance, or else 0.5-1 g/kg body weight in children or 50 g in adults. Repeated application is indicated for intoxications with agents that persist for a longer time in the stomach and for intoxications with timed-release drugs or drugs with a marked enterohepatic or entero-enteric circulation. The routine combination of activated charcoal with a laxative is not recommended.
conclusionEven though intoxications are common, there is still no internationally valid guideline concerning the administration of activated charcoal. A precise analysis of the risks and benefits is needed for each administration, and a poison control center should be consulted for this purpose.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.