Evidence map›Paper›PMID 31219000›Full record

Trial reportThe American journal of tropical medicine and hygiene2019

In Situ Cellular Response Underlying Successful Treatment of Mucosal Leishmaniasis with a Combination of Pentavalent Antimonial and Pentoxifylline.

Daniela Rodrigues de Faria, Luiza Cenizio Barbieri, Carolina Cattoni Koh, Paulo Roberto Lima Machado, Carolina Cincurá Barreto, Clara Monica Figueiredo de Lima, Marcus Miranda Lessa, Edgar Carvalho, Kenneth J Gollob, Walderez Ornelas Dutra

Open access · bronzeAbstract readRandomized Controlled Trial
In one paragraph

Trial report in The American journal of tropical medicine and hygiene, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Daniela Rodrigues de FariaCentro Universitário de Formiga - UNIFOR-MG, Formiga, Brazil.
Luiza Cenizio BarbieriLaboratory of Cell-Cell Interactions, Department of Morphology, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Carolina Cattoni KohLaboratory of Cell-Cell Interactions, Department of Morphology, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Paulo Roberto Lima MachadoInstituto Nacional de Ciência e Tecnologia em Doenças Tropicais - INCT-DT, Salvador, Brazil.
Carolina Cincurá BarretoImmunology Service, Hospital Universitário Professor Edgar Santos, Universidade Federal da Bahia, Salvador, Brazil.
Clara Monica Figueiredo de LimaImmunology Service, Hospital Universitário Professor Edgar Santos, Universidade Federal da Bahia, Salvador, Brazil.
Marcus Miranda LessaImmunology Service, Hospital Universitário Professor Edgar Santos, Universidade Federal da Bahia, Salvador, Brazil.
Edgar CarvalhoInstituto Nacional de Ciência e Tecnologia em Doenças Tropicais - INCT-DT, Salvador, Brazil.
Kenneth J GollobInternational Research Center, ACCamargo Cancer Center, São Paulo, Brazil.
Walderez Ornelas DutraLaboratory of Cell-Cell Interactions, Department of Morphology, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Universidade Federal de Minas Gerais · BRComplexo Hospitalar Universitário Professor Edgard Santos · BRUniversidade Federal da Bahia · BRInstituto Nacional de Ciência e Tecnologia de Doenças Tropicais · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mucosal leishmaniasis (ML) is characterized by high production of inflammatory cytokines. Administration of pentoxifylline (PTX), an inhibitor of TNF-alpha, with pentavalent antimony (Sb

Indexed as

AdultAgedAntimonyAntiprotozoal AgentsCytokinesDouble-Blind MethodDrug Therapy, CombinationFemaleGranzymesHumansInflammationLeishmaniasis, MucocutaneousMaleMiddle AgedPentoxifyllineRandom AllocationAntimonyAntiprotozoal AgentsCytokinesGranzymesPentoxifyllineTumor Necrosis Factor-alpha

Identifiers

PMID31219000
PMCPMC6685560
OpenAlexW2951627431

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.