Evidence map›Paper›PMID 31218941›Full record

ArticleTissue engineering. Part C, Methods2019

Optimization of Tissue-Engineered Vascular Graft Design Using Computational Modeling.

Jason M Szafron, Abhay B Ramachandra, Christopher K Breuer, Alison L Marsden, Jay D Humphrey

Abstract read
In one paragraph

Article in Tissue engineering. Part C, Methods, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Review
  2. Mechanics and mechanobiology of arterial development.Biomechanics and modeling in mechanobiology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. A computational framework to optimize the mechanical behavior of synthetic vascular grafts.Journal of the mechanical behavior of biomedical materials · 2025
    Article
  12. Article
  13. Review
  14. Article
  15. Hemodynamics and Wall Mechanics of Vascular Graft Failure.Arteriosclerosis, thrombosis, and vascular biology · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Tissue Engineering of Vascular Grafts: A Case Report From Bench to Bedside and Back.Arteriosclerosis, thrombosis, and vascular biology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jason M SzafronDepartment of Biomedical Engineering, Yale University, New Haven, Connecticut.
Abhay B RamachandraDepartment of Biomedical Engineering, Yale University, New Haven, Connecticut.
Christopher K BreuerRegenerative Medicine Program, Nationwide Children's Hospital, Columbus, Ohio.
Alison L MarsdenDepartments of Pediatrics and Bioengineering, Stanford University, Stanford, California.
Jay D HumphreyDepartment of Biomedical Engineering, Yale University, New Haven, Connecticut.

Funding

Improving Tissue Engineered Vascular Graft Performance via Computational ModelingR01HL139796 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI BREUER, CHRISTOPHER KANE, HUMPHREY, JAY D. · 2018 to 2025
$6.4M
Mechanisms of Vascular Neotissue Formation In Tissue Engineered Vascular GraftsR01HL098228 · NHLBI · YALE UNIVERSITY · PI BREUER, CHRISTOPHER KANE · 2010 to 2018
$3.6M
Computational Model Driven Design of Tissue Engineered Vascular GraftsR01HL128602 · NHLBI · YALE UNIVERSITY · PI BREUER, CHRISTOPHER KANE, HUMPHREY, JAY D. · 2015 to 2018
$2.2M
NHLBI NIH HHS R01 HL098228NHLBI NIH HHS R01 HL128602NHLBI NIH HHS R01 HL139796
6 · The paper itself

Abstract

Tissue-engineered vascular grafts hold great promise in many clinical applications, especially in pediatrics wherein growth potential is critical. A continuing challenge, however, is identification of optimal scaffold parameters for promoting favorable neovessel development. In particular, given the countless design parameters available, including those related to polymeric microstructure, material behavior, and degradation kinetics, the number of possible scaffold designs is almost limitless. Advances in computationally modeling the growth and remodeling of native blood vessels suggest that similar simulations could help reduce the search space for candidate scaffold designs in tissue engineering. In this study, we meld a computational model of

Indexed as

Blood Vessel ProsthesisComputer SimulationProsthesis DesignTissue EngineeringAnimalsInflammationMice, SCIDPolymersTissue ScaffoldsPolymerscomputational modelinginflammationmechanobiologyoptimizationscaffold

Identifiers

PMID31218941
PMCPMC6791486

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.