ArticleWiley interdisciplinary reviews. Systems biology and medicine2020
Neutrophils in innate immunity and systems biology-level approaches.
Article in Wiley interdisciplinary reviews. Systems biology and medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Diagnostic accuracy of neutrophil-to-lymphocyte ratio in type 2 diabetic nephropathy: a meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Kinetics of cell-free DNA in response to exogenous and exertional heating in healthy young men.European journal of applied physiology · 2026Trial
- Perioperative Inflammatory Biomarkers and Surgical Site Infection After Pelvic and Acetabular Fracture Surgery: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Cytokine trajectories after cardiopulmonary bypass in children: a systematic review and quantitative synthesis.International journal of cardiology. Congenital heart disease · 2026Article
- Lipoic Acid Attenuates Lipopolysaccharide- andInternational journal of molecular sciences · 2026Article
- SodA promotes immune evasion ofMicrobiology spectrum · 2026Article
- Melatonin at the Crossroads of Oxidative Stress, Immunity, and Cancer Therapy.Antioxidants (Basel, Switzerland) · 2026Review
- Ferroptosis-related genes MDM2 and CDKN1A as potential biomarkers for COPD.Journal of inflammation (London, England) · 2025Article
- Different neutrophil extracellular trap related Ewing sarcoma subtypes exhibit distinct prognosis, and immune microenvironment characteristics.Scientific reports · 2025Article
- Integrative Analysis of Dog Serum-Derived CircRNA Expression and Disease Severity, Inflammatory and Cardiac Damage Biomarkers Related to Canine Parvoviral Enteritis.Veterinary medicine and science · 2025Article
- Deep insight into cytokine storm: from pathogenesis to treatment.Signal transduction and targeted therapy · 2025Review
- The Aggregate Index of Systemic Inflammation (AISI) is a Novel IgA Nephropathy Prognosis Predictor.Journal of inflammation research · 2025Article
- Associations between neutrophil-lymphocyte ratio with all-cause mortality, major adverse vascular events and progression of diabetic kidney disease in type 2 diabetes mellitus.Frontiers in endocrinology · 2025Article
- The interplay between hormonal vitamin D and lipopolysaccharide signaling on human neutrophil transcriptional responses.Frontiers in immunology · 2025Article
- Immunomodulatory actions of tonifying polysaccharides: pharmacological effects, mechanisms and therapeutic applications.Frontiers in immunology · 2025Review
- A novel indicator for predicting functional recovery in elderly hip fracture patients.Frontiers in medicine · 2025Article
- Dendritic Cell-Related Immune Marker CD1C for Predicting Prognosis and Immunotherapy Opportunities of Lung Adenocarcinoma Patients.Applied biochemistry and biotechnology · 2024Article
- Significance of respiratory virus coinfection in children with Mycoplasma pneumoniae pneumonia.BMC pulmonary medicine · 2024Article
- Identification of Calculous Pyonephrosis by CT-Based Radiomics and Deep Learning.Bioengineering (Basel, Switzerland) · 2024Article
- Construction of an alignment diagram model for predicting calculous obstructive pyonephrosis before PNL.Heliyon · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The innate immune system is the first line of host defense against invading microorganisms. Polymorphonuclear leukocytes (PMNs or neutrophils) are the most abundant leukocyte in humans and essential to the innate immune response against invading pathogens. Compared to the acquired immune response, which requires time to develop and is dependent on previous interaction with specific microbes, the ability of neutrophils to kill microorganisms is immediate, nonspecific, and not dependent on previous exposure to microorganisms. Historically, studies of PMN-pathogen interaction focused on the events leading to killing of microorganisms, such as recruitment/chemotaxis, transmigration, phagocytosis, and activation, whereas postphagocytosis sequelae were infrequently considered. In addition, it was widely accepted that human neutrophils possessed limited capacity for new gene transcription and thus, relatively little biosynthetic capacity. This notion has changed dramatically within the past 20 years. Further, there is now more effort directed to understand the events occurring in PMNs after killing of microbes. Herein, we give an updated review of the systems biology-level approaches that have been used to gain an enhanced view of the role of neutrophils during host-pathogen interaction and neutrophil-mediated diseases. We anticipate that these and future systems-level studies will continue to provide information important for understanding, treatment, and control of diseases caused by pathogenic microorganisms. This article is categorized under: Physiology > Organismal Responses to Environment Physiology > Mammalian Physiology in Health and Disease Biological Mechanisms > Cell Fates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.