Evidence map›Paper›PMID 31218815›Full record

ReviewTraffic (Copenhagen, Denmark)2019

Germ granules in Drosophila.

Tatjana Trcek, Ruth Lehmann

Abstract readReview
In one paragraph

Review in Traffic (Copenhagen, Denmark), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed.

  1. Article
  2. Article
  3. Differential mRNA localization of karyopherin-β2 homologs inbioRxiv : the preprint server for biology · 2026
    Article
  4. Review
  5. Review
  6. LOTUS-domain proteins activate Vasa to drive germ granule assembly.bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Leveraging CRISPR-Cas13d in an inducible knockdown system to interrogatebioRxiv : the preprint server for biology · 2025
    Article
  11. eIF4E assembly intobioRxiv : the preprint server for biology · 2025
    Article
  12. Article
  13. Article
  14. Abundant piRNA production mediated by theProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tatjana TrcekHHMI, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, NYU School of Medicine, New York, New York.ORCID 0000-0003-4405-8733
Ruth LehmannHHMI, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, NYU School of Medicine, New York, New York.ORCID 0000-0002-8454-5651

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Aristotelis Tsirigos · 1985 to 2026
$83.1M
Germ Cell Migration in Drosophila.R37HD041900 · NICHD · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI LEHMANN, RUTH · 2013 to 2021
$2.6M
Mechanisms of mRNA localization to Drosophila germ granulesR00HD088675 · NICHD · JOHNS HOPKINS UNIVERSITY · PI TRCEK, TATJANA · 2019 to 2021
$733k
Mechanisms of mRNA localization to Drosophila germ granulesK99HD088675 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TRCEK, TATJANA · 2017 to 2018
$239k
NCI NIH HHS P30 CA016087NICHD NIH HHS K99 HD088675NICHD NIH HHS R00 HD088675NICHD NIH HHS R37 HD041900
6 · The paper itself

Abstract

Germ granules are hallmarks of all germ cells. Early ultrastructural studies in Drosophila first described these membraneless granules in the oocyte and early embryo as filled with amorphous to fibrillar material mixed with RNA. Genetic studies identified key protein components and specific mRNAs that regulate germ cell-specific functions. More recently these ultrastructural studies have been complemented by biophysical analysis describing germ granules as phase-transitioned condensates. In this review, we provide an overview that connects the composition of germ granules with their function in controlling germ cell specification, formation and migration, and illuminate these mysterious condensates as the gatekeepers of the next generation.

Indexed as

AnimalsCytoplasmic GranulesDrosophila melanogasterDrosophila ProteinsGametogenesisGerm CellsRNADrosophila ProteinsRNAgerm granuleslocalized translationmRNA clustersOskarphase separationRNA granulesRNA localizationvasa, nanos

Identifiers

PMID31218815
PMCPMC6771631

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.