Evidence map›Paper›PMID 31218753›Full record

ArticleMagnetic resonance in medicine2019

A thermally polarized

Elianna A Bier, John C Nouls, Ziyi Wang, Mu He, Geoff Schrank, Naomi Morales-Medina, Ralph Hashoian, Harvey Svetlik, John P Mugler, Bastiaan Driehuys

Open access · greenAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Magnetic resonance in medicine · 2025
    Article
  2. A thermally polarized, dissolved-phaseJournal of magnetic resonance (San Diego, Calif. : 1997) · 2025
    Article
  3. Article
  4. Article
  5. In vivo methods and applications of xenon-129 magnetic resonance.Progress in nuclear magnetic resonance spectroscopy · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Elianna A BierDepartment of Biomedical Engineering, Duke University, Durham, North Carolina.ORCID 0000-0002-2313-3450
John C NoulsCenter for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina.ORCID 0000-0003-2504-7625
Ziyi WangDepartment of Biomedical Engineering, Duke University, Durham, North Carolina.ORCID 0000-0002-8523-5161
Mu HeCenter for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina.
Geoff SchrankCenter for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina.
Naomi Morales-MedinaMedical Physics Graduate Program, Duke University, Durham, North Carolina.
Ralph HashoianClinical MR Solutions, Brookfield, Wisconsin.
Harvey SvetlikHarvey Svetlik Consulting, LLC., Grand Prairie, Texas.
John P MuglerRadiology & Medical Imaging, University of Virginia, Charlottesville, Virginia.
Bastiaan DriehuysDepartment of Biomedical Engineering, Duke University, Durham, North Carolina.
Duke University · USDuke Medical Center · USClinical Research Solutions · USSVT Associates (United States) · USUniversity of Virginia · US

Funding

Early Detection of Changes in Pulmonary Gas Exchange by Hyperpolarized Xe MRIR01HL105643 · NHLBI · DUKE UNIVERSITY · PI Bastiaan Driehuys · 2011 to 2026
$6.7M
Using MRI To Visualize Regional Therapy Response In Idiopathic Pulmonary FibrosisR01HL126771 · NHLBI · DUKE UNIVERSITY · PI Bastiaan Driehuys · 2015 to 2026
$6.6M
Training in Medical ImagingT32EB001040 · NIBIB · DUKE UNIVERSITY · PI NIGHTINGALE, KATHRYN RADABAUGH · 2003 to 2018
$4.4M
NHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS R01 HL105643NHLBI NIH HHS R01 HL126771NIBIB NIH HHS T32 EB001040
6 · The paper itself

Abstract

purposeHyperpolarized

methodsMR-compatible pressure vessels, with an internal volume of 5.85 L, were constructed from pressure-rated, engineering grade PE4710 high-density polyethylene. They were filled with a mixture of 61% natural xenon and 39% oxygen to approximately 11.6 bar and placed in a loader shell filled with a 0.56% saline solution to mimic the human chest. Imaging employed a 2D spoiled gradient-echo sequence using non-slice-selective excitation (TR/TE = 750/6.13 ms, flip angle = 74°, FOV = 40 × 440 mm, matrix = 64 × 32, bandwidth = 30 Hz/pixel, averages = 4), resulting in a 1.6 min acquisition. System characterization and imaging were performed at 8 different MRI centers.

resultsAt 3 Telsa,

conclusionThe high-density polyethylene pressure vessels filled with thermally polarized xenon and associated loader shell combine to form a phantom assembly that enables spectroscopic and imaging acquisitions that can be used for testing, quality assurance, and performance tracking-capabilities essential for standardizing hyperpolarized

Indexed as

Xenon IsotopesEquipment DesignHumansMagnetic Resonance ImagingPhantoms, ImagingXenon Isotopes129Xe MR129Xe phantomphantomquality assurancethermally polarized

Identifiers

PMID31218753
PMCPMC6660390
OpenAlexW2952130955

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.