ArticleJournal of clinical laboratory analysis2019
Potential prognostic factors for predicting the chemotherapeutic outcomes and prognosis of patients with metastatic colorectal cancer.
Article in Journal of clinical laboratory analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Prognostic and clinicopathological value of fibrinogen-to-albumin ratio in colorectal cancer: a meta-analysis.Annals of medicine · 2025Pooled it
- Cancer-derived inflammation is associated with bevacizumab resistance and inferior clinical outcomes in patients with metastatic colorectal cancer.Therapeutic advances in medical oncology · 2026Article
- Preoperative albumin-to-fibrinogen ratio as a predictor of postoperative hospital stay in locally advanced esophageal squamous cell carcinoma after neoadjuvant therapy.Scientific reports · 2025Article
- Preoperative malnutrition is a risk factor for prolonged postoperative ileus for patients undergoing gastrointestinal surgery.Frontiers in nutrition · 2025Article
- A nomogram of inflammatory indexes for preoperatively predicting the risk of lymph node metastasis in colorectal cancer.Techniques in coloproctology · 2024Article
- The predictive value of the preoperative albumin-to-fibrinogen ratio for postoperative hospital length of stay in liver cancer patients.Cancer medicine · 2023Article
- The Prognostic value of the Fibrinogen to pre-albumin ratio in malignant tumors of the digestive system: a systematic review and meta-analysis.Cancer cell international · 2022Review
- Fibrinogen-Albumin Ratio Index Exhibits Predictive Value of Neoadjuvant Chemotherapy in Osteosarcoma.Cancer management and research · 2022Article
- The prognostic value of sarcopenia combined with preoperative fibrinogen-albumin ratio in patients with intrahepatic cholangiocarcinoma after surgery: A multicenter, prospective study.Cancer medicine · 2021Article
- Fibrinogen-to-Albumin Ratio is Associated with All-Cause Mortality in Cancer Patients.International journal of general medicine · 2021Article
- Research Progress of Preoperative FPR, FAR or AFR in Patients with Colorectal Cancer.Cancer management and research · 2021Review
- A novel prognostic risk score model based on immune-related genes in patients with stage IV colorectal cancer.Bioscience reports · 2020Article
- Prognostic value of fibrinogen-to-albumin ratio in patients with gastric cancer receiving first-line chemotherapy.Oncology letters · 2020Article
- Preoperative fibrinogen-to-albumin ratio, a potential prognostic factor for patients with stage IB-IIA cervical cancer.BMC cancer · 2020Article
- Albumin-fibrinogen ratio and fibrinogen-prealbumin ratio as promising prognostic markers for cancers: an updated meta-analysis.World journal of surgical oncology · 2020Review
- Prealbumin-to-Globulin Ratio Can Predict the Chemotherapy Outcomes and Prognosis of Patients with Gastric Cancer Receiving First-Line Chemotherapy.Journal of immunology research · 2020Article
- Sodium to globulin ratio as a prognostic factor for patients with advanced gastric cancer.Journal of Cancer · 2020Article
- Preoperative Fibrinogen-Albumin Ratio Index (FARI) is a Reliable Prognosis and Chemoradiotherapy Sensitivity Predictor in Locally Advanced Rectal Cancer Patients Undergoing Radical Surgery Following Neoadjuvant Chemoradiotherapy.Cancer management and research · 2020Article
- Potential prognostic factors for predicting the chemotherapeutic outcomes and prognosis of patients with metastatic colorectal cancer.Journal of clinical laboratory analysis · 2019Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe purpose of this study was to explore whether pretreatment potential prognostic factors are related to chemotherapeutic outcomes and the prognosis of inpatients with metastatic colorectal cancer (mCRC) undergoing chemotherapy. MATERIALS AND
methodsData from 71 patients with mCRC were analyzed retrospectively. The relationship between the potential prognostic factors before first-line chemotherapy and the clinicopathological characteristics and chemotherapy response of the patients was calculated using Fisher's exact test and the chi-square test. The prognostic factors were analyzed using univariate and multivariate analyses. We analyzed the subgroups using the Mann-Whitney U test.
resultsFour factors were eventually used as prognostic factors, namely the albumin-to-globulin ratio (AGR), the fibrinogen-to-albumin ratio (FAR), the prealbumin-to-globulin ratio (PGR), and the fibrinogen-to-prealbumin ratio (FPR); the cutoff values of the four potential prognostic factors were 1.40, 10.63, 5.44, and 18.49, respectively. The high AGR and PGR groups had a higher response rate than that of the low groups. Patients in the low FAR and FPR groups showed a higher objective response rate than the high FAR and FPR groups. Patients with low FPR were associated with a higher disease control rate than patients with high FPR. Higher progression-free survival (PFS) was observed in the high AGR and PGR and low FAR and FPR groups. The AGR, FAR, PGR, and FPR were considered reliable prognostic factors for PFS in a univariate analysis.
conclusionsThe prechemotherapy AGR, FAR, PGR, and FPR were good prognostic factors to predict the chemotherapy response and PFS in patients with mCRC.
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