SynthesisActa psychiatrica Scandinavica2019
A systematic review and meta-analysis of clinical predictors of lithium response in bipolar disorder.
Synthesis in Acta psychiatrica Scandinavica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- PD-1/PD-L1 inhibitors in treatment-naïve, advanced non-small cell lung cancer patients with < 1% PD-L1 expression: a meta-analysis of randomized controlled trials.Journal of cancer research and clinical oncology · 2023Pooled it
- A systematic review and meta-analysis of treatments for rapid cycling bipolar disorder.Acta psychiatrica Scandinavica · 2022Pooled it
- A systematic review and meta-analysis of clinical predictors of lithium response in bipolar disorder.Acta psychiatrica Scandinavica · 2019Pooled it
- Trial
- Effect of lithium administration on brain activity under an emotion regulation paradigm in healthy participants: a functional magnetic resonance imaging study.Psychopharmacology · 2023Trial
- A Randomized, Double-Blind, Controlled Trial of Lithium Versus Quetiapine for the Treatment of Acute Mania in Youth with Early Course Bipolar Disorder.Journal of child and adolescent psychopharmacology · 2021Trial
- Bipolar Disorder XI: Continuous Decline of Lithium Response Inversely Correlated to Time Before Drug Administration in Relation to Onset of a Bipolar Disorder.Biological psychiatry global open science · 2026Article
- Towards precision psychiatry: initial foundations and future directions.Nature reviews. Drug discovery · 2026Review
- Assessing molecular gene by treatment interactions using a population of neural progenitors exposed to valproic acid and lithium.Molecular psychiatry · 2026Article
- Bipolar Disorder VI: Long-Term Follow-Up of Suicide Attempts and Prophylactic Effect of Lithium Treatment in Bipolar Affective Disorder.Biological psychiatry global open science · 2026Article
- Data-driven symptom dimensions reveal familial patterns in bipolar disorder.Journal of affective disorders · 2026Article
- Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder.medRxiv : the preprint server for health sciences · 2026Article
- Lithium prescription patterns for bipolar disorder at a psychiatric hospital in KwaZulu-Natal.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2026Article
- Response and Adverse Effects to Lithium Treatment in Patients With Bipolar Disorder at Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia.BioMed research international · 2026Article
- Overlap and Divergence in Ketamine and Lithium Response in Bipolar Disorder: A Scoping Review.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Genome-wide methylation biomarkers and biological aging in patients with bipolar disorder characterized for lithium response.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Genetic variants in GRIN2B and NTRK2 on the etiology and treatment response to valproate and lithium in patients with bipolar disorder.Pharmacological reports : PR · 2025Article
- Beyond "Fire" and "Ashes": The Influence of Trait Characteristics on the Response to Mood Stabilizers in Bipolar Disorders.Brain sciences · 2025Article
- The Potential of Using Screening Tools for Bipolar Disorder to Predict Lithium Response.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Letter to the editor regarding the article, "Type of cycle, temperament and childhood trauma are associated with lithium response in patients with bipolar disorders".International journal of bipolar disorders · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveTo determine clinical predictors of lithium response in bipolar disorder.
methodsSystematic review of studies examining clinical predictors of lithium response was conducted. Meta-analyses were performed when ≥2 studies examined the same potential predictor.
resultsA total of 71 studies, including over 12 000 patients, identified six predictors of good response: mania-depression-interval sequence [odds ratio (OR): 4.27; 95% CI: 2.61, 6.97; P < 0.001], absence of rapid cycling (OR for rapid cycling: 0.30; 95% CI: 0.17, 0.53; P < 0.001), absence of psychotic symptoms (OR for psychotic symptoms: 0.52; 95% CI: 0.34, 0.79; P = 0.002), family history of bipolar disorder (OR: 1.61; 95% CI: 1.03, 2.52; P = 0.036), shorter prelithium illness duration [standardised mean difference (SMD): -0.26; 95% CI: -0.41, -0.12; P < 0.001] and later age of onset (SMD: 0.17; 95% CI: 0.02, 0.36; P = 0.029). Additionally, higher body mass index was associated with poor response in two studies (SMD: -0.61; 95% CI: -0.90, -0.32; P < 0.001). There was weak evidence for number of episodes prior to lithium treatment (SMD: -0.42; 95% CI: -0.84, -0.01; P = 0.046), number of hospitalisations before lithium (SMD: -0.40; 95% CI: -0.81, 0.01; P = 0.055) and family history of lithium response (OR: 10.28; 95% CI: 0.66, 161.26; P = 0.097).
conclusionsThe relative importance of these clinical characteristics should be interpreted with caution because of potential biases and confounding.
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Registered trials
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