Evidence map›Paper›PMID 31218656›Full record

ArticleForensic science, medicine, and pathology2019

Massive intracranial bleeding due to the rupture of a rare spontaneous pseudoaneurysm of the middle cerebral artery in a pediatric patient: case report with clinical, radiological, and pathologic findings.

Lorenzo Gitto, Timothy E Richardson, Serenella Serinelli, Francesco Diana, Simone Peschillo, Maurizio Domenicucci

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Forensic science, medicine, and pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Large intraparenchymal hematoma revealing an intracranial pseudoaneurysm in a newborn discovered during surgery.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Lorenzo GittoDepartment of Pathology, State University of New York - Upstate Medical University, 750 E Adams St, Syracuse, NY, 13210, USA. gittol@upstate.edu.ORCID http://orcid.org/0000-0002-1435-1819
Timothy E RichardsonDepartment of Pathology, Neuropathology Laboratory, State University of New York - Upstate Medical University, 750 E. Adam St, Syracuse, NY, 13210, USA.
Serenella SerinelliDepartment of Pathology, State University of New York - Upstate Medical University, 750 E Adams St, Syracuse, NY, 13210, USA.
Francesco DianaDepartment of Interventional Neuroradiology, University of Catania, Catania, Italy.
Simone PeschilloDepartment of Neurosurgery, Endovascular Neurosurgery, University of Catania, Catania, Italy.
Maurizio DomenicucciDepartment of Neurology and Psychiatry, Division of Neurosurgery, Sapienza University of Rome, Rome, Italy.
SUNY Upstate Medical University · USUniversity of Catania · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracranial pseudoaneurysm (IPA) is a rare but likely underdiagnosed cause of intracranial hemorrhage, which accounts for just 1-6% of all intracranial aneurysms. Spontaneous IPAs are exceptionally rare, and their etiology and features are not well defined. Herein, we report a case of a pediatric patient who died from massive intracranial bleeding due to the rupture of a spontaneous IPA after undergoing multiple radiological studies and neurosurgical operations. At the postmortem examination of the brain, a giant size pseudoaneurysm of the right middle cerebral artery was observed. Microscopic examination demonstrated variable wall thickness and dense fibrosis focally in the vessel wall with disruption of the media structure together with a loss and fragmentation of the elastic laminae, loss of organization of smooth muscle cells in the media, and multifocal areas of hemorrhage throughout the vessel wall, as well as direct evidence of wall dissection. Since IPAs without any traumatic or infective history are extremely uncommon, further pathologic studies should be performed to clarify spontaneous pseudoaneurysm etiology.

Indexed as

Aneurysm, FalseIntracranial AneurysmIntracranial HemorrhagesMiddle Cerebral ArteryAdolescentComputed Tomography AngiographyFatal OutcomeFemaleHumansImaging, Three-DimensionalRupture, SpontaneousTomography, X-Ray ComputedForensic pathologyIntracranial bleedingNeuropathologyNeurosurgeryPediatric patientPseudoaneurysm

Identifiers

PMID31218656
OpenAlexW2951789191

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.