Evidence map›Paper›PMID 31218572›Full record

ArticleJournal of the American Society for Mass Spectrometry2019

Structure, Anion, and Solvent Effects on Cation Response in ESI-MS.

Isaac Omari, Parmissa Randhawa, Jaiya Randhawa, Jenny Yu, J Scott McIndoe

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Isaac OmariDepartment of Chemistry, University of Victoria, PO Box 1700 STN CSC, Victoria, BC, V8W 2Y2, Canada.
Parmissa RandhawaDepartment of Chemistry, University of Victoria, PO Box 1700 STN CSC, Victoria, BC, V8W 2Y2, Canada.
Jaiya RandhawaDepartment of Chemistry, University of Victoria, PO Box 1700 STN CSC, Victoria, BC, V8W 2Y2, Canada.
Jenny YuDepartment of Chemistry, University of Victoria, PO Box 1700 STN CSC, Victoria, BC, V8W 2Y2, Canada.
J Scott McIndoeDepartment of Chemistry, University of Victoria, PO Box 1700 STN CSC, Victoria, BC, V8W 2Y2, Canada. mcindoe@uvic.ca.ORCID http://orcid.org/0000-0001-7073-5246

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The abundance of an ion in an electrospray ionization mass spectrum is dependent on many factors beyond just solution concentration. Even in cases where the analytes of interest are permanently charged (under study here are ammonium and phosphonium ions) and do not rely on protonation or other chemical processes to acquire the necessary charge, factors such as cation structure, molecular weight, solvent, and the identity of the anion can affect results. Screening of a variety of combinations of cations, anions, and solvents provided insight into some of the more important factors. Rigid cations and anions that conferred high conductivity tended to provide the highest responses. The solvent that most closely reflected actual solution composition was acetonitrile, while methanol, acetonitrile/water, and dichloromethane produced a higher degree of discrimination between different ions. Functional groups that had affinity for the solvent tended to depress response. These observations will provide predictive power when accounting for analytes that for reasons of high reactivity can not be isolated.

Indexed as

CounterionsElectrospray ionizationResponse factorSolvent effectsStructure

Identifiers

PMID31218572

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.