Evidence map›Paper›PMID 31218541›Full record

ArticleMolecular biology reports2019

The A allele of the UCP2 -866G/A polymorphism changes UCP2 promoter activity in HUVECs treated with high glucose.

Daisy Crispim, Michelle Rodrigues, Liana Paula Abreu da Silva, Ana Paula Bouças, Luís Henrique Canani, Rodrigo Carlessi, Bianca Marmontel de Souza

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. PP2 Ameliorates Renal Fibrosis by Regulating the NF-Oxidative medicine and cellular longevity · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Daisy CrispimEndocrine Division, Hospital de Clínicas de Porto Alegre, Ramiro Barcelos Street, Number 2350, Building 12, 4° Floor, Porto Alegre, Rio Grande do Sul, 90035-003, Brazil.ORCID http://orcid.org/0000-0001-5095-9269
Michelle RodriguesEndocrine Division, Hospital de Clínicas de Porto Alegre, Ramiro Barcelos Street, Number 2350, Building 12, 4° Floor, Porto Alegre, Rio Grande do Sul, 90035-003, Brazil.
Liana Paula Abreu da SilvaEndocrine Division, Hospital de Clínicas de Porto Alegre, Ramiro Barcelos Street, Number 2350, Building 12, 4° Floor, Porto Alegre, Rio Grande do Sul, 90035-003, Brazil.
Ana Paula BouçasPost Graduation Program in Medical Sciences: Endocrinology, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Luís Henrique CananiEndocrine Division, Hospital de Clínicas de Porto Alegre, Ramiro Barcelos Street, Number 2350, Building 12, 4° Floor, Porto Alegre, Rio Grande do Sul, 90035-003, Brazil.ORCID http://orcid.org/0000-0002-1813-4491
Rodrigo CarlessiSchool of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Kent St, Bentley, Perth, 6102, WA, Australia.ORCID http://orcid.org/0000-0003-0038-7391
Bianca Marmontel de SouzaEndocrine Division, Hospital de Clínicas de Porto Alegre, Ramiro Barcelos Street, Number 2350, Building 12, 4° Floor, Porto Alegre, Rio Grande do Sul, 90035-003, Brazil. bisouza@gmail.com.ORCID http://orcid.org/0000-0001-8414-8878
Universidade Federal do Rio Grande do Sul · BRHospital de Clínicas de Porto Alegre · BRCurtin University · AU

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) scholarshipFundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS) 16/2551-0000 476-5
6 · The paper itself

Abstract

The mitochondrial uncoupling protein 2 (UCP2) decreases reactive oxygen species (ROS) formation by mitochondria. Our group previously showed that the UCP2 -866A allele was associated with risk of diabetic retinopathy (DR), which is caused by hyperglycemia-induced oxidative stress. To date, it is still unclear if the -866A allele directly affects UCP2 expression in endothelial cells. Thus, we investigated the effect of the A allele on UCP2 promoter activity in HUVECs treated with high glucose (HG) or hydrogen peroxide (H

Indexed as

AllelesGenotypePolymorphism, Single NucleotidePromoter Regions, GeneticGenes, ReporterGlucoseHumansHuman Umbilical Vein Endothelial CellsHydrogen PeroxideOxidative StressUncoupling Protein 2GlucoseHydrogen PeroxideUCP2 protein, humanUncoupling Protein 2Diabetic retinopathyEndothelial cellsHigh glucoseOxidative stressUCP2 polymorphism

Identifiers

PMID31218541
OpenAlexW2950209037

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.