ArticleJournal of materials science. Materials in medicine2019
In vitro study on cytocompatibility and osteogenesis ability of Ti-Cu alloy.
Article in Journal of materials science. Materials in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Recent Advances in Copper-Doped Titanium Implants.Materials (Basel, Switzerland) · 2022Review
- Promoting osteointegration effect of Cu-alloyed titanium in ovariectomized rats.Regenerative biomaterials · 2022Article
- In Vitro Characterization of In Situ Alloyed Ti6Al4V(ELI)-3 at.% Cu Obtained by Laser Powder Bed Fusion.Materials (Basel, Switzerland) · 2021Article
- Article
- Anodic TiONanomaterials (Basel, Switzerland) · 2021Review
- Copper-based biomaterials for bone and cartilage tissue engineering.Journal of orthopaedic translation · 2021Review
- Biological applications of copper-containing materials.Bioactive materials · 2021Review
- The Effect of Copper Content on the Mechanical and Tribological Properties of Hypo-, Hyper- and Eutectoid Ti-Cu Alloys.Materials (Basel, Switzerland) · 2020Article
- Msx2 plays an important role in BMP6-induced osteogenic differentiation of two mesenchymal cell lines: C3H10T1/2 and C2C12.Regenerative therapy · 2020Article
- Article
- Nano-Modified Titanium Implant Materials: A Way Toward Improved Antibacterial Properties.Frontiers in bioengineering and biotechnology · 2020Review
- The Fabrication and Function of Strontium-modified Hierarchical Micro/Nano Titanium Implant.International journal of nanomedicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Titanium implants easily suffer bacteria-related infections in clinic due to their inherent lack of self-protection ability. Therefore, a novel Ti-Cu alloy with good antibacterial activity has been developed as a new kind of implant material. This study focuses on a systematic evaluation of both cytocompatibility and osteogenesis activity of the Ti-Cu alloy in vitro. It was revealed that an addition of 5% Cu into pure Ti would not cause any negative effect on osteoblasts adhesion, proliferation and apoptosis cultured with Ti-Cu alloy. In addition, Ti-Cu alloy could significantly promote the osteogenic differentiation of MG 63 cells by upregulating the osteogenesis-related gene expressions including alkaline phosphatase (ALP), Collagen I (Colla I), osteopontin (OPN) and osteocalcin (OCN). These promising results suggest that the Ti-Cu alloy has great potential to be used as a multi-functional titanium implant for clinical applications.
Indexed as
Identifiers
31218519What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.