Evidence map›Paper›PMID 31218104›Full record

ArticleAmerican journal of cancer research2019

Type Iγ phosphatidylinositol phosphate kinase dependent cell migration and invasion are dispensable for tumor metastasis.

Shiheng Li, Chunhua Chen, Xunhao Xiong, Yan Huang, Jinghua Hu, Zhimin Fan, Kun Ling

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Shiheng LiDepartment of Breast Surgery, The First Hospital of Jilin University 71 Xinmin Street, Changchun, Jilin Province, China.
Chunhua ChenDepartment of Biochemistry and Molecular Biology, Mayo Clinic 200 First Street SW, Rochester, MN 55902, USA.
Xunhao XiongDepartment of Pathology, The University of Oklahoma Health Sciences Center 940 Stanton L Young Blvd, Oklahoma City, Oklahoma, USA.
Yan HuangDepartment of Biochemistry and Molecular Biology, Mayo Clinic 200 First Street SW, Rochester, MN 55902, USA.
Jinghua HuDepartment of Biochemistry and Molecular Biology, Mayo Clinic 200 First Street SW, Rochester, MN 55902, USA.
Zhimin FanDepartment of Breast Surgery, The First Hospital of Jilin University 71 Xinmin Street, Changchun, Jilin Province, China.
Kun LingDepartment of Biochemistry and Molecular Biology, Mayo Clinic 200 First Street SW, Rochester, MN 55902, USA.
Mayo Clinic · USJilin University · CNUniversity of Oklahoma Health Sciences Center · US

Funding

Pilot and FeasibilityP30DK090728 · NIDDK · MAYO CLINIC ROCHESTER · PI TORRES, VICENTE E · 2010 to 2019
$11.8M
Molecular dissection of the ciliary gateR01DK099160 · NIDDK · MAYO CLINIC ROCHESTER · PI Jinghua Hu · 2014 to 2026
$4.0M
Exploration of the functions of the ciliopathy Arls in cilia.R01DK090038 · NIDDK · MAYO CLINIC ROCHESTER · PI HU, JINGHUA · 2011 to 2019
$3.1M
NIDDK NIH HHS P30 DK090728NIDDK NIH HHS R01 DK090038NIDDK NIH HHS R01 DK099160
6 · The paper itself

Abstract

Type Iγ phosphatidylinositol phosphate kinase (PIPKIγ) has been associated with poor prognosis in breast cancer patients by promoting metastasis. Among the six alternative-splicing isoforms of PIPKIγ, PIPKIγ_i2 specifically targets to focal adhesions and regulates focal adhesion turnover, thus was proposed responsible for tumor metastasis. In the present study, we specifically depleted PIPKIγ_i2 from mouse triple negative breast cancer (TNBC) 4T1 cells and analyzed their behaviors. As expected, PIPKIγ_i2-depleted 4T1 cells exhibited reduced proliferation, migration, and invasion

Indexed as

cell migrationmetastasisPIPKIγthe epithelial-to-mesenchymal transitiontriple negative breast cancer

Identifiers

PMID31218104
PMCPMC6556613
OpenAlexW2994916426

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.