ArticleSAGE open medicine2019
Potential drug-drug interactions and associated factors among hospitalized cardiac patients at Jimma University Medical Center, Southwest Ethiopia.
Article in SAGE open medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Medication-related problems and their associated factors among paediatric patients in Ethiopia: a systematic review and meta-analysis.BMJ paediatrics open · 2026Pooled it
- Prevalence of potential drug-drug interactions and associated factors among outpatients and inpatients in Ethiopian hospitals: a systematic review and meta-analysis of observational studies.BMC pharmacology & toxicology · 2020Pooled it
- Potential drug-drug interactions in hospitalized patients with acute coronary syndrome at a tertiary care hospital in upper Egypt.Frontiers in pharmacology · 2026Article
- A comprehensive landscape of AI applications in broad-spectrum drug interaction prediction: a systematic review.Journal of cheminformatics · 2025Review
- Potential drug-drug interactions among hospitalised cardiac patients in Nepal: a prospective observational study.BMJ open · 2025Observational
- Risk Factors and Patterns of Drug-Drug Interactions in Two Categories of Level-3 Hospitals in Dhaka: A Cross-Sectional Study.Health science reports · 2025Article
- Assessment of Potential Drug-drug Interactions (pDDIs) and Their Risk Factors Among Hospitalized Cardiac Patients in a Tertiary-care Center of Central India: A Retrospective Record-based Study.Hospital pharmacy · 2024Article
- Potential drug-drug interactions among U.S. adults treated with nirmatrelvir/ritonavir: A cross-sectional study of the National Covid Cohort Collaborative (N3C).Pharmacotherapy · 2023Article
- Frequency, Predictors, and Outcomes of the Potential Drug-Drug Interactions in the ICUs of Teaching Hospitals in Ardabil, Northwest of Iran During 2019-2020.Hospital pharmacy · 2023Article
- Article
- Potential Drug-Drug Interactions in a Cardiac Center: Development of Simple Software for Pattern Identification.The journal of Tehran Heart Center · 2022Article
- Developing a desktop application for drug-drug interaction checker ordered for chronic diseases in Ethiopian hospitals pharmacy.BMC pharmacology & toxicology · 2022Article
- The Prevalence of Potential Drug-Drug Interactions in CKD-A Retrospective Observational Study of Cerrahpasa Nephrology Unit.Medicina (Kaunas, Lithuania) · 2022Observational
- Potential drug-drug interactions in patients with cardiovascular diseases: findings from a prospective observational study.Journal of pharmaceutical policy and practice · 2021Article
- Drug-Drug interaction among admitted patients at primary, district and referral hospitals' medical wards in East Gojjam Zone, Amhara Regional State, Ethiopia.SAGE open medicine · 2021Article
- Prevalence of potential drug-drug interactions in outpatients of a general hospital in China: a retrospective investigation.International journal of clinical pharmacy · 2020Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundConcomitant use of several drugs for a patient is often imposing increased risk of drug-drug interactions. Drug-drug interactions are a major cause for concern in patients with cardiovascular disorders due to multiple co-existing conditions and the wide class of drugs they receive. This study is aimed to assess the prevalence of potential drug-drug interactions and associated factors among hospitalized cardiac patients at medical wards of Jimma University Medical Center, Southwest Ethiopia.
methodsA hospital-based prospective observational study was conducted among hospitalized cardiac adult patients based on the inclusion criteria. Patient-specific data were collected using structured data collection tool. Potential drug-drug interaction was analyzed using Micromedex 3.0 DRUG-REAX
resultsOf the total 200 patients, majority were male (52.50%) and with a mean(±standard deviation) age of 42.54(±7.89) years. Out of 673 patients' prescriptions analyzed, 521 prescriptions comprised potential drug interactions and it was found that 967 drug interactions were present. The prevalence rate of potential drug-drug interactions among the study unit was 4.83 per patient and 1.44 per prescription regardless of the severity during their hospital stay. Overall the prevalence rate of potential drug interactions was 74.41%. Older age (adjusted odds ratio (95% confidence interval): 1.067 (2.33-27.12), p = 0.049), long hospital stay (⩾7 days) (adjusted odds ratio (95% confidence interval): 2.80 (1.71-4.61), p = 0.024), and polypharmacy (adjusted odds ratio (95% confidence interval): 1.64 (0.66-4.11), p = 0.041) were independent predictors for the occurrence of potential drug-drug interactions.
conclusionThis study demonstrated a high prevalence of potential DIs among hospitalized cardiac patients in medical wards due to the complexity of pharmacotherapy. The prevalence rate is directly related to age, number of prescribed drugs, and length of hospital stay. Pharmacodynamic drug-drug interaction was the common mechanism of drug-drug interactions. Therefore, close monitoring of hospitalized patients is highly recommended.
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