ArticleJRSM cardiovascular disease
Increased blood pressure variability after acute ischemic stroke increases the risk of death: A secondary analysis of the Virtual International Stroke Trial Archive.
Article in JRSM cardiovascular disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Effect of dihydropyridine calcium channel blockers on blood pressure variability in the SPRINT trial: a treatment effects approach.Journal of hypertension · 2022Trial
- Asian expert consensus on high-quality hypertension management.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Review
- Relationship Between Routine Preoperative Chest CT-Based Cardiac Parameters and Recanalization After Mechanical Thrombectomy in Patients with Acute Ischemic Stroke.Journal of clinical medicine · 2026Article
- Intensified blood pressure control during hospital admission and on discharge: a systematic review and meta-analysis of retrospective cohort studies.Frontiers in cardiovascular medicine · 2026Review
- Observational
- Impaired Peripheral Vascular Function Following Ischemic Stroke in Mice: Potential Insights into Blood Pressure Variations in the Post-Stroke Patient.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024Article
- Stroke Related Brain-Heart Crosstalk: Pathophysiology, Clinical Implications, and Underlying Mechanisms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Blood Pressure Variability in Acute Stroke: A Narrative Review.Journal of clinical medicine · 2024Review
- Better Blood Pressure Control for Stroke Patients in the ICU: A Deep Reinforcement Learning with Supervised Guidance Approach for Adaptive Infusion Rate Tuning.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2024Article
- Blood pressure variability and early neurological outcomes in acute and subacute stroke in Southwestern Uganda.eNeurologicalSci · 2023Article
- Association of Blood Pressure Variability With Death and Discharge Destination Among Critically Ill Patients With and Without Stroke.Neurology · 2023Article
- Prediction of blood pressure variability during thrombectomy using supervised machine learning and outcomes of patients with ischemic stroke from large vessel occlusion.Journal of thrombosis and thrombolysis · 2023Article
- Prognostic significance of blood pressure parameters after mechanical thrombectomy according to collateral status.BMC neurology · 2023Article
- Blood pressure variability, nocturnal heart rate variability and endothelial function predict recurrent cerebro-cardiovascular events following ischemic stroke.Frontiers in cardiovascular medicine · 2023Article
- Within-Person Blood Pressure Variability During Hospitalization and Clinical Outcomes Following First-Ever Acute Ischemic Stroke.American journal of hypertension · 2023Article
- Interaction of Mean Arterial Pressure and Blood Pressure Variability in Critically Ill Brain Injured Patients.Stroke · 2022Article
- The potential therapeutic benefits of low frequency haemodynamic oscillations.The Journal of physiology · 2022Article
- Brain-heart interaction after acute ischemic stroke.Critical care (London, England) · 2020Review
- Article
- Associations of Interleukin 10, Matrix Metallopeptidase 9, and Legumain with Blood Pressure Variability and Neurologic Outcomes in Patients with Ischemic Stroke.International journal of general medicine · 2020Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundDespite promising epidemiological data, it remains unclear if increased blood pressure variability is associated with death after acute ischemic stroke. Our objective was to examine this association in a large cohort of acute ischemic stroke patients.
methodsWe conducted a retrospective analysis of anonymized, pooled, participant data from the Virtual International Stroke Trial Archive. We included patients with a 90-day modified Rankin Scale and blood pressure readings in the 24 h after study enrollment. The exposure was blood pressure variability during the day after study enrollment, calculated for the systolic and diastolic blood pressure using six statistical methodologies. The primary outcome was death within 90 days of stroke onset.
resultsOur cohort comprised 1891 patients of whom 277 (14.7%) died within 90 days. All indices of blood pressure variability were higher in patients who died, but the difference was more pronounced for systolic than diastolic blood pressure variability (systolic standard deviation for alive versus dead patients = 13.4 versus 15.9 mmHg, p < 0.001). Similar results were found in logistic regression models fit to the outcome of death, but only systolic blood pressure variability remained significant in adjusted models (Odds Ratio for death when comparing highest to lowest tercile of systolic blood pressure variability = 1.41-1.89, p < 0.03 for all).
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