ArticleIranian journal of basic medical sciences2019
Probiotic supplementation improves the cognitive function and the anxiety-like behaviors in the stressed rats.
Article in Iranian journal of basic medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Microbial Legacy: Mycobacterium vaccae ATCC 15483Molecular psychiatry · 2026Article
- High‑fat diet and cognitive dysfunction: Mechanistic insights into diet‑induced neurodegeneration (Review).International journal of molecular medicine · 2026Review
- Nutritional interventions to counteract the detrimental consequences of early-life stress.Molecular psychiatry · 2025Review
- Probiotics restore impaired spatial cognition and synaptic plasticity of prenatally-stressed male rats: focus on hippocampal and intestinal tight junctions.Neurobiology of stress · 2025Article
- Lactobacillus fermentum MCC2760 attenuates neurobehavioral alterations induced by oxidized oils in rats.Metabolic brain disease · 2024Article
- Limosilactobacillus reuteri ameliorates maternal separation stress in newborn mice and alters subsequent adult behaviour.Beneficial microbes · 2024Article
- Health position paper and redox perspectives - Disease burden by transportation noise.Redox biology · 2024Review
- Review
- Potential benefits of yeastFrontiers in veterinary science · 2023Review
- A review of the auditory-gut-brain axis.Frontiers in neuroscience · 2023Review
- The role of probiotics and prebiotics in modulating of the gut-brain axis.Frontiers in nutrition · 2023Review
- Perspective on the relationship between microbiota dysbiosis and neuroinflammation: probiotics as a treatment option.Neural regeneration research · 2022Article
- Heat-inactivated Lacticaseibacillus paracasei N1115 alleviates the damage due to brain function caused by long-term antibiotic cocktail exposure in mice.BMC neuroscience · 2022Article
- Effects of nano-curcumin on noise stress-induced hippocampus-dependent memory impairment: behavioral and electrophysiological aspects.Pharmacological reports : PR · 2022Article
- A Reciprocal Link Between Gut Microbiota, Inflammation and Depression: A Place for Probiotics?Frontiers in neuroscience · 2022Review
- Association Between Consumption of Fermented Food and Food-Derived Prebiotics With Cognitive Performance, Depressive, and Anxiety Symptoms in Psychiatrically Healthy Medical Students Under Psychological Stress: A Prospective Cohort Study.Frontiers in nutrition · 2022Article
- Transportation noise pollution and cardiovascular disease.Nature reviews. Cardiology · 2021Review
- Gut microbiota: a new player in the pathogenesis of perioperative neurocognitive disorder?Ibrain · 2021Review
- Most Effective Combination of Nutraceuticals for Improved Memory and Cognitive Performance in the House Cricket,Nutrients · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPrenatal stresses increase incidence of neurodevelopmental disorders and influence cognitive abilities. Glucocorticoids are released in stress condition as endpoint activation of hypothalamus-pituitary-adrenal (HPA) axis. Evidence indicates a cross-talk between gut microbiota and brain function. This study assesses the effect of probiotic supplementation on behavioral functionand HPA axis action in stressed rats. MATERIALS AND
methodsThe young rats born from dams exposed to noise stress (ST) during third trimester of pregnancy were used. Two groups of stressed animals were received a two-week probiotic supplementation before (pre-ST) and after (post-ST) birth. The time and distance to find hidden platform in Morris water maze were evaluated as spatial memory. Also entry to open arms in elevated plus-maze was considered as anxiety-like behaviors. The serum level of corticosterone was measured as the HPA axis function.
resultsWhile the stressed rats decreased entries to open arms to one third compared to the controls (CON) the probiotic treatment increased the entries by two times. The ST rats required more time and distance to find the platform than did the CON animals. The pre- and post-ST rats significantly restored the impaired behavior almost near the CON ones. While the serum corticosterone concentration increased by 50% in the ST rats it was reduced to almost normal level in the pre- and post-ST rats.
conclusionOur findings confirmed a link between the gut microbiome and probiotics with the behavioral functions and HPA axis. The probiotic treatment favorably affected the stress-dependent behavioral disorders and the interaction between HPA and gut-brain-microbiota axes.
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