ArticleAmerican journal of translational research2019
Long noncoding RNA TUG1 promotes airway smooth muscle cells proliferation and migration via sponging miR-590-5p/FGF1 in asthma.
Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 49 citations in OpenAlex.
- Review
- Identification of STAT3 signaling as a shared pathogenic signature in systemic lupus erythematosus, chronic obstructive pulmonary disease, and asthma.Scientific reports · 2025Article
- Noncoding RNAs in asthmatic airway smooth muscle cells.European respiratory review : an official journal of the European Respiratory Society · 2023Review
- Chronic allergic asthma alters m6A epitranscriptomic tagging of mRNAs and lncRNAs in the lung.Bioscience reports · 2022Article
- New developments in the biology of fibroblast growth factors.WIREs mechanisms of disease · 2022Review
- Long noncoding RNA ANRIL up-regulates CCND1 via sponging miR-98-5p to promote TGF-β1-induced human airway smooth muscle cell proliferation, migration, and extracellular matrix deposition.The Kaohsiung journal of medical sciences · 2022Article
- Construction and analysis of a ceRNA network and patterns of immune infiltration in chronic rhinosinusitis with nasal polyps: based on data mining and experimental verification.Scientific reports · 2022Article
- Integrated analysis of mRNA and long noncoding RNA profiles in peripheral blood mononuclear cells of patients with bronchial asthma.BMC pulmonary medicine · 2022Article
- Review
- Article
- The Novel Regulatory Role of the lncRNA-miRNA-mRNA Axis in Chronic Inflammatory Airway Diseases.Frontiers in molecular biosciences · 2022Review
- Article
- Emerging Advances of Non-coding RNAs and Competitive Endogenous RNA Regulatory Networks in Asthma.Bioengineered · 2021Review
- Long non-coding RNA TUG1 promotes proliferation and migration in PDGF-BB-stimulated HASMCs by regulating miR-216a-3p/SMURF2 axis.BMC molecular and cell biology · 2021Article
- Long non-coding RNA TUG1 accelerates abnormal growth of airway smooth muscle cells in asthma by targeting the miR-138-5p/E2F3 axis.Experimental and therapeutic medicine · 2021Article
- Inhibition of LOXL1-AS1 alleviates oxidative low-density lipoprotein induced angiogenesis via downregulation of miR-590-5p mediated KLF6/VEGF signaling pathway.Cell cycle (Georgetown, Tex.) · 2021Article
- LncRNA MALAT1 promotes proliferation and migration of airway smooth muscle cells in asthma by downregulating microRNA-216a.Saudi journal of biological sciences · 2021Article
- GAS5 regulates viability and apoptosis in TGF-β1-stimulated bronchial epithelial cells by regulating miR-217/HDAC4 axis.Genes & genomics · 2021Article
- A long noncoding RNA antisense to ICAM-1 is involved in allergic asthma associated hyperreactive response of airway epithelial cells.Mucosal immunology · 2021Article
- Role of Non-Coding RNAs in Post-Transcriptional Regulation of Lung Diseases.Frontiers in genetics · 2021Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The proliferation and migration of airway smooth muscle cells (ASMCs) plays an important role in asthma. Recently, the function of long noncoding RNA (lncRNA) in the ASMCs has been realized. This study tries to investigate the role of lncRNA TUG1 for the ASMCs and focus on the deepgoing mechanism in the proliferation and migration. In the asthma rat model, TUG1 expression level was increased comparing with control. In the cellular assay with gain and loss of functions, lncRNA TUG1 promoted the ASMCs proliferation and migration, and reduces apoptosis. In the mechanical investigation, results unveiled that miR-590-5p acted as the target of TUG1, while FGF1 was targeted by miR-590-5p. Overall, this study reveals the vital regulation of TUG1/miR-590-5p/FGF1 axis for the proliferation and migration of ASMCs.
Indexed as
Identifiers
31217885PMC6556671W3023689391What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.