ArticleAmerican journal of translational research2019
LncRNA RMRP/miR-613 axis is associated with poor prognosis and enhances the tumorigenesis of hepatocellular carcinoma by impacting oncogenic phenotypes.
Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 26 citations in OpenAlex.
- LncRMRP drives bladder cancer invasion via a lactylation-driven positive feedback circuit.Oncogene · 2026Article
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- Human lncRNAProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Deciphering the roles of cellular and extracellular non-coding RNAs in chemotherapy-induced cardiotoxicity.Molecular and cellular biochemistry · 2025Review
- Identification and Assessment of lncRNAs and mRNAs in PM2.5-Induced Hepatic Steatosis.International journal of molecular sciences · 2025Article
- A Swedish genome-wide haplotype association analysis identifies novel candidate loci associated with endometrial cancer risk.PloS one · 2025Article
- Long noncoding RNA MALAT-1: A versatile regulator in cancer progression, metastasis, immunity, and therapeutic resistance.Non-coding RNA research · 2024Review
- Abnormal expression of long non-coding RNAs RMRP, CTC-487M23.5, and DGCR5 in the peripheral blood of patients with Bipolar disorder.Metabolic brain disease · 2024Article
- Article
- lncRNA MALAT1 promotes HCC metastasis through the peripheral vascular infiltration via miRNA-613: a primary study using contrast ultrasound.World journal of surgical oncology · 2022Article
- Exosomal LncRNA RP5-977B1 as a novel minimally invasive biomarker for diagnosis and prognosis in non-small cell lung cancer.International journal of clinical oncology · 2022Article
- Bioinformatics Study Revealed Significance of Exosome Transcriptome in Hepatocellular Carcinoma Diagnosis.Frontiers in cell and developmental biology · 2022Article
- Long Noncoding RNA RMRP Contributes to Paclitaxel Sensitivity of Ovarian Cancer by Regulating miR-580-3p/MICU1 Signaling.Journal of oncology · 2022Article
- lncRNA RMRP predicts poor prognosis and mediates tumor progression of esophageal squamous cell carcinoma by regulating miR-613/ neuropilin 2 (NRP2) axis.Bioengineered · 2021Article
- Interactions between long non‑coding RNAs and RNA‑binding proteins in cancer (Review).Oncology reports · 2021Review
- Long Noncoding-RNA Component of Mitochondrial RNA Processing Endoribonuclease Promotes Carcinogenesis in Triple-Negative Breast Cancer Cells via the Competing Endogenous RNA Mechanism.Journal of breast cancer · 2021Article
- ALKBH5-mediated m6A demethylation of lncRNA RMRP plays an oncogenic role in lung adenocarcinoma.Mammalian genome : official journal of the International Mammalian Genome Society · 2021Article
- The long noncoding RNA of RMRP is downregulated by PERK, which induces apoptosis in hepatocellular carcinoma cells.Scientific reports · 2021Article
- POU2F1 Promotes Cell Viability and Tumor Growth in Gastric Cancer through Transcriptional Activation of lncRNA TTC3-AS1.Journal of oncology · 2021Article
- Long Non-coding RNA RMRP in the Pathogenesis of Human Disorders.Frontiers in cell and developmental biology · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing evidences demonstrate that long noncoding RNAs (lncRNAs) play an important role in the tumorigenesis of hepatocellular carcinoma (HCC). LncRNA RMRP (RNA component of mitochondrial RNA processing endoribonuclease) has been proved to involve in the tumorigenesis of several human cancers. However, the role and molecular mechanism of RMRP in HCC remain largely unknown. In current study, we compared the expression profiles of RMRP in 52 paired HCC specimens and corresponding adjacent non-tumor tissues. The clinicopathological characteristics of HCC patients in relation to RMRP expression were analyzed, and the prognostic value of RMRP expression was examined. RNAi technology was performed to knockdown RMRP expression in HCC cells, and the effects of RMRP on cell proliferation, cell cycle, migration and invasion of HCC cells were assessed by using MTT, flow cytometry, wound scratch and transwell invasion assays. The potential binding site of RMRP to miR-613 was confirmed by using dual luciferase reporter gene and qRT-PCR assays. Here, we found that RMRP expression was significantly upregulated in the HCC tissues and cells, and high RMRP expression was positively correlated with tumor aggressive phenotypes and poor overall survival of patients with HCC. Furthermore, RMRP knockdown suppressed cell proliferation, migration, invasion and induced cell cycle arrest at G0/G1 phase. The expression of miR-613 was dramatically down-regulated in HCC tissues and cells, and RMRP could negatively regulate miR-613 expression by acting as a ceRNA. In mechanism, RMRP exerted an oncogenic role in HCC via downregulation of miR-613.
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Identifiers
31217855PMC6556662W2983486956What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.